Synthesis and antineoplastic activity of cyclolignan aldehydes.

Gordaliza M; Castro MA; Miguel del-Corral-JM; Lopez Vazquez-ML; A Garcia-P; Garcia Gravalos-MD; San Feliciano-A

首页> 外文期刊>European Journal of Medicinal Chemistry: Chimie Therapeutique >Synthesis and antineoplastic activity of cyclolignan aldehydes.

【24h】

Synthesis and antineoplastic activity of cyclolignan aldehydes.

机译：环木脂醛的合成及其抗肿瘤活性。

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Several aldehydes related to methyl 9-deoxy-9-oxo-alpha-apopicropodophyllate, a selective antitumour agent against the HT-29 colon carcinoma, have been prepared and evaluated for their cytotoxic activities on four neoplastic cell lines (P-388, A-549, HT-29 and MEL-28). All of them lacked the lactone ring but maintained their cytotoxicity at, or under, the &mgr;M level.

机译：已经制备了几种与HT-29结肠癌的选择性抗肿瘤药9-脱氧-9-氧代-α-apopicropodophyllate甲基有关的醛，并评估了它们对四种肿瘤细胞系的细胞毒活性（P-388，A- 549，HT-29和MEL-28）。他们所有人都没有内酯环，但是将细胞毒性维持在或低于M水平。

著录项

来源
《European Journal of Medicinal Chemistry: Chimie Therapeutique》 |2000年第8期|共8页
作者
Gordaliza M; Castro MA; Miguel del-Corral-JM; Lopez Vazquez-ML; A Garcia-P; Garcia Gravalos-MD; San Feliciano-A;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类医药、卫生;
关键词
Aldehydes; Antineoplastic Agents; Lignans; 醛类; 抗肿瘤药; 木酚素类;

机译：Aldehydes;Antineoplastic Agents;Lignans;醛类;抗肿瘤药;木酚素类;

相似文献

外文文献
中文文献
专利

1. Synthesis and antineoplastic activity of cyclolignan aldehydes. [J] . Gordaliza M, Castro MA, Miguel del-Corral-JM, European Journal of Medicinal Chemistry: Chimie Therapeutique . 2000,第7a8期

机译：环木脂醛的合成及其抗肿瘤活性。
2. Antineoplastic Activity, Structural Modification, Synthesis and Structure-activity Relationship of Dammarane-type Ginsenosides: An Overview [J] . Zhang Qiang, Wang Xude, Lv Liyan, Current organic chemistry . 2019,第5期

机译：达摩甘油型人参皂苷的抗肿瘤活性，结构改性，合成和结构 - 活性关系：概述
3. Synthesis, characterization and antineoplastic activity of bis-aziridinyl dimeric naphthoquinone - A novel class of compounds with potent activity against acute myeloid leukemia cells [J] . Carter-Cooper Brandon A., Fletcher Steven, Ferraris Dana, Bioorganic and Medicinal Chemistry Letters . 2017,第1期

机译：双 - 氮杂乙烯基二聚体萘醌的合成，表征和抗肿瘤活性 - 一种具有急性髓性白血病细胞的强效活性的新型化合物
4. Towards New Oligomeric Spirobifluorene Derivatives:Synthesis And Electrochemistry Of 2- And 2,2'-Spirobifluorene Aldehydes. [C] . Giulia Fioravanti, Leonardo Mattiello, Liliana Rampazzo The Meeting of the Electrochemical Society . 2001

机译：朝向新的低聚螺氟烯衍生物：2,2'-螺氟烯醛的合成和电化学。
5. Part I. Asymmetric organocatalysis: (1) Direct enantioselective organocatalytic hydroxymethylation of aldehydes catalyzed by alpha,alpha-diphenylprolinol trimethylsilyl ether: Application in the formal synthesis of (-)-Rasfonin; (2) Synthesis of a novel bicyclic secondary amine organocatalyst: Application to the direct enantioselective organocatalytic hydroxymethylation of aldehydes. Part II. Asymmetric synthesis of bicyclic analogues of the anti-osteoporotic drug risedronate. [D] . Miller, John Robert. 2010

机译：第一部分，不对称有机催化：（1）α，α-二苯基脯氨醇三甲基甲硅烷基醚催化的醛的直接对映选择性有机催化羟甲基化：在（-）-Rasfonin的正式合成中的应用；（2）新型双环仲胺有机催化剂的合成：应用于醛的直接对映选择性有机催化羟甲基化。第二部分抗骨质疏松药物Risedronate的双环类似物的不对称合成。
6. Synthesis characterization and antineoplastic activity of bis-aziridinyl dimeric naphthoquinone - a novel class of compounds with potent activity against acute myeloid leukemia cells [O] . Brandon A. Carter-Cooper, Steven Fletcher, Dana Ferraris, -1

机译：双氮丙啶基二聚萘醌的合成表征和抗肿瘤活性-一种新型的对急性髓性白血病细胞具有有效活性的化合物
7. Synthesis of Cyclic Derivatives of Tartaric Acid by Condensing Alkyld-Tartrates with Aromatic Aldehydes. (Optical Activity and Chemical Structure in Tartaric Acid. VI) [O] . Yojiro Tsuzuki 1939

机译：用芳族醛缩合丙基丙氨酸烯丙基酸的甘氨酸环状衍生物的合成。（酒石酸中的光学活性和化学结构。VI）

Synthesis and antineoplastic activity of cyclolignan aldehydes.

摘要

著录项

相似文献

相关主题

期刊订阅