Design, synthesis, and antifungal activity of triazole and benzotriazole derivatives.

Rezaei Z; Khabnadideh S; Pakshir K; Hossaini Z; Amiri F; Assadpour E

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Design, synthesis, and antifungal activity of triazole and benzotriazole derivatives.

机译：三唑和苯并三唑衍生物的设计，合成和抗真菌活性。

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This study describes the design, synthesis and evaluation of a novel series of 1,2,4-triazole and benzotriazole derivatives as inhibitors of cytochrome P450 14alpha-demethylase (14DM). The chemical structures of the new compounds were confirmed by elemental and spectral ((1)H NMR, (13)C NMR, Mass) analyses. Compounds were designed by a generating virtual library of compounds and docking them into the enzyme active site. Furthermore, they were found to have in vitro activity against Microsporum canis, Trichophyton mentagrophyte, Trichophyton rubrum, Epidermophyton floccosum, and Candida albicans comparable to fluconazole and clotrimazole.

机译：这项研究描述了一系列新型的1,2,4-三唑和苯并三唑衍生物作为细胞色素P45014α-脱甲基酶（14DM）抑制剂的设计，合成和评估。新化合物的化学结构通过元素分析和光谱分析（（1）H NMR，（13）C NMR，Mass）分析得到确认。通过生成化合物的虚拟文库并将其对接到酶活性位点中来设计化合物。此外，发现它们具有与氟康唑和克霉唑相当的体外抗犬小孢子菌，薄荷毛癣菌，红毛癣菌，絮状表皮菌和白色念珠菌的体外活性。

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《European Journal of Medicinal Chemistry: Chimie Therapeutique》 |2009年第7期|共4页
作者
Rezaei Z; Khabnadideh S; Pakshir K; Hossaini Z; Amiri F; Assadpour E;
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正文语种 eng
中图分类药学;
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1. Design, synthesis, and antifungal activity of triazole and benzotriazole derivatives. [J] . Rezaei Z, Khabnadideh S, Pakshir K, European Journal of Medicinal Chemistry: Chimie Therapeutique . 2009,第7期

机译：三唑和苯并三唑衍生物的设计，合成和抗真菌活性。
2. Design, synthesis and antifungal activities of novel 1,2,4-triazole derivatives. [J] . Xu J, Cao Y, Zhang J, European Journal of Medicinal Chemistry: Chimie Therapeutique . 2011,第7期

机译：新的1,2,4-三唑衍生物的设计，合成和抗真菌活性。
3. Design, synthesis, and antifungal activity of novel conformationally restricted triazole derivatives. [J] . Wang W, Sheng C, Che Archiv der Pharmazie . 2009,第12期

机译：新型构象受限的三唑衍生物的设计，合成和抗真菌活性。
4. Structure-Based Design, Synthesis, and Antifungal Activity of New Triazole Derivatives [C] . Chunquan Sheng, Xiaoying Che, Wenya Wang, International conference of molecular simulations and applied informatics technologies . 2012

机译：新三唑衍生物的基于结构的设计，合成和抗真菌活性
5. Synthesis of functionalized and of polymerizable and polymeric 2(2-hydroxyphenyl)2H-benzotriazole derivatives. [D] . Sustic, Andres Igor. 1992

机译：官能化的和可聚合的和聚合的2（2-羟苯基）2H-苯并三唑衍生物的合成。
6. Design Synthesis and Biological Activity of New Triazole and Nitro-Triazole Derivatives as Antifungal Agents [O] . Hossein Sadeghpour, Soghra Khabnadideh, Kamiar Zomorodian, 2017

机译：新三唑和硝基三唑衍生物作为抗真菌剂的设计合成和生物活性
7. Triazole Antifungals. IV. Synthesis and Antifungal Activities of 3-Acylamino-2-aryl-2-butanol Derivatives. [O] . Toshiyuki KONOSU, Yawara TAJIMA, Noriko TAKEDA, 1991

机译：三唑抗真菌。 IV。 3-酰基氨基-2-芳基-2-丁醇衍生物的合成和抗真菌活性。
8. Reactions of Benzotriazolo (2,1-alpha)benzotriazole Derivatives. I. Synthesis ofNew Insensitive High Density Energetic Compounds [R] . Subramanian, G., Boyer, J. H., Buzatu, D., 1995

机译：苯并三唑（2,1-α）苯并三唑衍生物的反应。 I.新的不敏感高密度含能化合物的合成

Design, synthesis, and antifungal activity of triazole and benzotriazole derivatives.

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