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首页> 外文期刊>European Journal of Medicinal Chemistry: Chimie Therapeutique >Spectrophotometric and HPLC determinations of anti-diabetic drugs, rosiglitazone maleate and metformin hydrochloride, in pure form and in pharmaceutical preparations.
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Spectrophotometric and HPLC determinations of anti-diabetic drugs, rosiglitazone maleate and metformin hydrochloride, in pure form and in pharmaceutical preparations.

机译：分光光度法和HPLC测定纯形式和药物制剂中的抗糖尿病药，马来酸罗格列酮和盐酸二甲双胍。

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摘要

In this study, three spectrophotometric methods and one HPLC method were developed for analysis of anti-diabetic drugs in tablets. The two spectrophotometric methods were based on the reaction of rosiglitazone (RSG) with 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) and bromocresol green (BCG). Linear relationship between the absorbance at lambda(max) and the drug concentration was found to be in the ranges 6.0-50.0 and 1.5-12 microg ml(-1) for DDQ and BCG methods, respectively. The third spectrophotometric method consists of a zero-crossing first-derivative spectrophotometric method for simultaneous analysis of RSG and metformin (MTF) in tablets. The calibration curves were linear within the concentration ranges of 5.0-50 microg ml(-1) for RSG and 1.0-10.0 microg ml(-1) for MTF. The fourth method is a rapid stability-indicating HPLC method developed for the determination of RSG. A linear response was observed within the concentration range of 0.25-2.5 microg ml(-1). The proposed methods have been successfully applied to the tablet analysis.
机译：在这项研究中，开发了三种分光光度法和一种HPLC方法来分析片剂中的抗糖尿病药。两种分光光度法是基于罗格列酮（RSG）与2,3-二氯-5,6-二氰基-1,4-苯醌（DDQ）和溴甲酚绿（BCG）的反应。对于DDQ和BCG方法，发现在λ（max）处的吸光度与药物浓度之间的线性关系分别在6.0-50.0和1.5-12 microg ml（-1）的范围内。第三种分光光度法由零交叉的一阶导数分光光度法组成，用于同时分析片剂中的RSG和二甲双胍（MTF）。校准曲线在RSG的5.0-50微克ml（-1）和MTF的1.0-10.0微克ml（-1）的浓度范围内是线性的。第四种方法是为测定RSG而开发的一种指示稳定性的快速HPLC方法。在0.25-2.5 microg ml（-1）的浓度范围内观察到线性响应。所提出的方法已经成功地应用于片剂分析。

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