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首页> 外文期刊>European Journal of Medicinal Chemistry: Chimie Therapeutique >Investigation of the antioxidant properties of some new 4-hydroxycoumarin derivatives.
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Investigation of the antioxidant properties of some new 4-hydroxycoumarin derivatives.

机译：一些新的4-羟基香豆素衍生物的抗氧化性能的研究。

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The aim of this investigation was to measure the activity of four 4-hydroxycoumarin derivatives - three of them were described before and one was newly synthesized. The substances were ethyl 2-[(4-hydroxy-2-oxo-2H-chromen-3-yl)(4-hydroxyphenyl)methyl]-3-oxobutanoate (SS-14), 4-[1-(4-hydroxy-2-oxo-2H-chromen-3-yl)-2-(ethoxycarbonyl)-3-oxobutyl]benzoic acid (SS-17), ethyl 2-[(4-hydroxy-2-oxo-2H-chromen-3-yl)(3-nitrophenyl)methyl]-3-oxobutanoate (SS-21) and ethyl 2-[(3,4,5-trimethoxyphenyl)(4-hydroxy-2-oxo-2H-chromen-3-yl)methyl]-3-oxobutanoat e (T-2). The synthesis of T-2 consists of two steps. First step was Knoevenagel reaction between 3,4,5-trimethoxybenzaldehyde and ethylacetoacetate. Ethyl 2-(3,4,5-trimethoxy)-phenylmethyleneacetoacetate was the product. Second step was Michael addition reaction between the latter product and 4-hydroxycoumarin. All the compounds were tested in vitro for antioxidant activity in hypochlorous system. The assay was based on the luminol-dependent chemiluminescence of free radicals, which decreased in the presence of 4-hydroxycoumarin derivative. Compound SS-14 (ethyl 2-[(4-hydroxy-2-oxo-2H-chromen-3-yl)(4-hydroxyphenyl)methyl]-3-oxobutanoate) expresses the best scavenger activity at the highest concentration (10(-4)mol/L).
机译：这项研究的目的是测量四种4-羟基香豆素衍生物的活性-以前已经描述了其中的三种，其中一种是新合成的。物质是2-[（（4-羟基-2-氧代-2H-铬-3-基）（4-羟基苯基）甲基] -3-氧代丁酸乙酯（SS-14），4- [1-（4-羟基）乙基-2-氧代-2H-铬-3-基）-2-（乙氧羰基）-3-氧丁基]苯甲酸（SS-17），乙基2-[（4-羟基-2-氧代-2H-铬3-） -（基）（3-硝基苯基）甲基] -3-氧代丁酸酯（SS-21）和2-[（3,4,5-三甲氧基苯基）（4-羟基-2-氧代-2H-铬-3-基）乙酯甲基] -3-氧代丁酸（T-2）。 T-2的合成包括两个步骤。第一步是3,4,5-三甲氧基苯甲醛与乙酰乙酸乙酯之间的Knoevenagel反应。 2-（3,4,5-三甲氧基）-苯基亚甲基乙酰乙酸乙酯是产物。第二步是后者产物与4-羟基香豆素之间的迈克尔加成反应。所有化合物均在次氯体系中进行了体外抗氧化活性测试。该测定基于自由基的鲁米诺依赖性化学发光，该自由基在4-羟基香豆素衍生物存在下降低。化合物SS-14（2-[（（4-羟基-2-氧代-2H-铬-3-基）（4-羟基苯基）甲基] -3-氧代丁酸乙酯）在最高浓度下表现出最好的清除剂活性（10（ -4）mol / L）。

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