Pyrrolo(1,2-f)phenanthridines and related non-rigid analogues as antiviral agents.

Almerico AnnaMaria; Mingoia Francesco; Diana Patrizia; Barraja Paola; Montalbano Alessandra; Lauria Antonino; Loddo Roberta; Sanna Laura; Delpiano Donatella; Setzu MariaGiovanna; Musiu Chiara

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Pyrrolo(1,2-f)phenanthridines and related non-rigid analogues as antiviral agents.

机译：吡咯并（1,2-f）菲啶和相关的非刚性类似物作为抗病毒剂。

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The pyrrolo[1,2-f]phenanthridines 8-22 and the corresponding non-rigid analogues 23-41 were synthesised and their ability to inhibit the replication of HIV-1 was tested. Only the polycyclic derivatives 10, 11, and 13 showed a weak anti-HIV activity, whereas several pyrrolo-phenanthridines (8, 10, 16-18) were found to stimulate the multiplication of MT-4 cells at low concentrations. Derivative 10 demonstrated to possess the unique property of stimulating the multiplication of lymphocytes joined to HIV inhibition.

机译：合成了吡咯并[1,2-f]菲啶8-22和相应的非刚性类似物23-41，并测试了它们抑制HIV-1复制的能力。仅多环衍生物10、11和13显示出弱的抗HIV活性，而发现一些吡咯并菲（8、10、16-18）在低浓度下刺激MT-4细胞的增殖。衍生物10被证明具有刺激结合HIV抑制作用的淋巴细胞增殖的独特特性。

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来源
《European Journal of Medicinal Chemistry: Chimie Therapeutique》 |2002年第1期|共8页
作者
Almerico AnnaMaria; Mingoia Francesco; Diana Patrizia; Barraja Paola; Montalbano Alessandra; Lauria Antonino; Loddo Roberta; Sanna Laura; Delpiano Donatella; Setzu MariaGiovanna; Musiu Chiara;
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正文语种 eng
中图分类医药、卫生;
关键词
Anti-HIV Agents; HIV Infections; HIV-1; Phenanthridines; Pyrroles; 抗HIV药; HIV感染; HIV-1; 菲啶类; 吡咯类;

机译：Anti-HIV Agents;HIV Infections;HIV-1;Phenanthridines;Pyrroles;抗HIV药;HIV感染;HIV-1;菲啶类;吡咯类;

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1. Pyrrolo(1,2-f)phenanthridines and related non-rigid analogues as antiviral agents. [J] . Almerico AnnaMaria, Mingoia Francesco, Diana Patrizia, European Journal of Medicinal Chemistry: Chimie Therapeutique . 2002,第1期

机译：吡咯并（1,2-f）菲啶和相关的非刚性类似物作为抗病毒剂。
2. EFFICIENT SYNTHESIS OF PYRROLO[1,2-f]-PHENANTHRIDINE DERIVATIVES VIA DIPOLAR CYCLOADDITION OF PHENANTHRIDINE, ACTIVATED ACETYLENES, AND ETHYL BROMOPYRUVATE [J] . Hossein Mehrabi, Jaleh Pishahang Synthetic Communications . 2014,第1a3期

机译：通过苯丙氨酸，活性乙炔和溴代丙酮酸二乙酯的双循环负载可高效合成吡咯并[1,2-f]-菲啶衍生物
3. Palladium-catalyzed synthesis of pyrimido[5 ',4 ':3,4]pyrrolo[1,2-f]phenanthridine-12, 14(11H,13H)-diones and related compounds [J] . Shevchenko M. A., Tkachenko Y. N., Astakhov A. V., Russian Chemical Bulletin . 2018,第9期

机译：钯催化合成嘧啶[5'，4'：3,4] Pyrrolo [1,2-F]菲啶-12,14（11h，13h） - 二酮和相关化合物
4. Preparation of New 5-Methylthio-6-nitro-1,2,4-triazolo 1,5-apyrimidine-7-ones as Structural Analogues of Antiviral Drugs [C] . D.N. Lyapustin, E.N. Ulomsky, E.K. Voinkov, International Conference on Modern Synthetic Methodologies for Creating Drugs and Functional Materials . 2019

机译：制备新的5-甲基-6-硝基-1,2,4-三唑唑1,5-a嘧啶-7-抗病毒药物的结构性类似物
5. Tricyclic purine analogues as antiparasitic and antiviral agents. [D] . Hagos, Asmerom M. 2003

机译：三环嘌呤类似物作为抗寄生虫药和抗病毒药。
6. Synthesis and Antiproliferative Activity of Thiazolyl-bis-pyrrolo23-bpyridines and Indolyl-thiazolyl-pyrrolo23-cpyridines Nortopsentin Analogues [O] . Anna Carbone, Barbara Parrino, Gloria Di Vita, 2015

机译：噻唑基-双-吡咯并23-b吡啶和吲哚基-噻唑基-吡咯并23-c吡啶的合成及抗增殖活性
7. Anti-tumour heterocycles : part 16 : the synthesis of 7,10-dimethoxyellipticine and its pyrrolo2,3-fcarbazole and pyrrolo3,2-f analogues [O] . Dharmasena Pryanthi, Campos Ana M. F. Oliveira, Queiroz Maria João R. P., 1997

机译：抗肿瘤杂环化合物：第16部分：7,10-二甲氧基玫瑰树碱及其吡咯并2,3-f咔唑和吡咯并3,2-f类似物的合成
8. Antimalarial Activities in New Pyrrolo(3,2-f) Quinazoline-1,3-Diamine Derivatives [R] . Guan, J. , Zhang, Q. , O'Neil, M. , 2005

机译：新吡咯并（3,2-f）喹唑啉-1,3-二胺衍生物中的抗疟活性

Pyrrolo(1,2-f)phenanthridines and related non-rigid analogues as antiviral agents.

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