Synthesis of novel tetrahydroimidazole derivatives and studies for their biological properties.

Sharma V; Khan MS

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Synthesis of novel tetrahydroimidazole derivatives and studies for their biological properties.

机译：新型四氢咪唑衍生物的合成及其生物学性质的研究。

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Ethylenediamine was reacted with suitable aromatic aldehydes in order to prepare their respective diSchiff bases. These compounds were then reduced to give the corresponding tetrahydrodiSchiff bases, which were low melting in nature. Finally, these derivatives were condensed with different aromatic aldehydes to give the desired tetrahydroimidazoles. The structures of all these compounds were established on the basis of spectral data. These novel tetrahydroimidazoles showed promising anti-inflammatory and analgesic activity. The compounds were also screened for their anti-bacterial property against Staphylococcus aureus and Escherichia coli.

机译：使乙二胺与合适的芳族醛反应以制备它们各自的二席夫碱。然后将这些化合物还原，得到相应的四氢二席夫碱，其本质上是低熔点的。最后，将这些衍生物与不同的芳族醛缩合，得到所需的四氢咪唑。所有这些化合物的结构都是根据光谱数据确定的。这些新颖的四氢咪唑显示出有希望的抗炎和止痛活性。还对化合物针对金黄色葡萄球菌和大肠杆菌的抗菌性能进行了筛选。

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《European Journal of Medicinal Chemistry: Chimie Therapeutique》 |2001年第8期|共8页
作者
Sharma V; Khan MS;
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原文格式 PDF
正文语种 eng
中图分类医药、卫生;
关键词
Analgesics; Anti-Infective Agents; Anti-Inflammatory Agents; Escherichia coli; 镇痛药; 抗感染药; 消炎药; 大肠杆菌; 咪唑类; 葡萄球菌; 金黄色;

机译：Analgesics;Anti-Infective Agents;Anti-Inflammatory Agents;Escherichia coli;镇痛药;抗感染药;消炎药;大肠杆菌;咪唑类;葡萄球菌;金黄色;

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Synthesis of novel tetrahydroimidazole derivatives and studies for their biological properties.

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