Esters of chlorambucil with 2-substituted 1,4-dihydroxy-9,10-anthraquinones as multifunctional anticancer agents.

Jin G; You Y; Kim Y; Nam N; Ahn B

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Esters of chlorambucil with 2-substituted 1,4-dihydroxy-9,10-anthraquinones as multifunctional anticancer agents.

机译：苯丁酸氮芥酯与2-取代的1,4-二羟基-9,10-蒽醌作为多功能抗癌药。

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Novel twelve esters of chlorambucil with 2-(1-hydroxyalkyl)-1,4-dihydroxy-9,10-anthraquinone were synthesized and tested for their antitumor activity in mice bearing S-180 ascitic cells as well as cytotoxic activity against L1210 cells. Eight of them were highly cytotoxic on L1210 cells (ED(50), <6 &mgr;gmL(-1)) and derivatives 1 and 12 (T/C, 200 and 205%) appeared more active in vivo than chlorambucil (T/C, 168%).

机译：合成了苯丁酸氮芥与2-（1-羟烷基）-1,4-二羟基-9,10-蒽醌的新型十二种酯，并测试了它们在荷有S-180腹水细胞的小鼠中的抗肿瘤活性以及对L1210细胞的细胞毒活性。其中有八种对L1210细胞具有高度的细胞毒性（ED（50），<6 gmL（-1）），并且衍生物1和12（T / C，200和205％）在体内的活性比苯丁酸氮芥（T / C）高。 C，168％）。

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《European Journal of Medicinal Chemistry: Chimie Therapeutique》 |2001年第4期|共6页
作者
Jin G; You Y; Kim Y; Nam N; Ahn B;
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原文格式 PDF
正文语种 eng
中图分类医药、卫生;
关键词
Esters; Chlorambucil; -1; Cells; 酯类; 苯丁酸氮芥; 细胞;

机译：Esters;Chlorambucil;-1;Cells;酯类;苯丁酸氮芥;细胞;

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1. Esters of chlorambucil with 2-substituted 1,4-dihydroxy-9,10-anthraquinones as multifunctional anticancer agents. [J] . Jin G, You Y, Kim Y, European Journal of Medicinal Chemistry: Chimie Therapeutique . 2001,第4期

机译：苯丁酸氮芥酯与2-取代的1,4-二羟基-9,10-蒽醌作为多功能抗癌药。
2. Interaction of 1,4-dihydroxy-9,10-anthraquinone with Calf thymus DNA: A comparison with anthracycline anticancer drugs [J] . Guin P.S., Das S., Mandal P.C. Journal of Solution Chemistry . 2011,第3期

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3. Design, synthesis and biological evaluation of estradiol-chlorambucil hybrids as anticancer agents. [J] . Gupta A, Saha P, Descoteaux C, Bioorganic and Medicinal Chemistry Letters . 2010,第5期

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4. Structural, Optical and Photovoltaic Studies on Schottky Barrier Devices using 1,4-Dihydroxy-9, 10-Anthraquinone Films [C] . Aman Mahajan, R.K.Bedl Indian Vacuum Society National Symposium on Vacuum Science amp; Technology and Vacuum Metallurgy(IVSNS 2003); 20031015-17; Mumbai(IN) . 2003

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Esters of chlorambucil with 2-substituted 1,4-dihydroxy-9,10-anthraquinones as multifunctional anticancer agents.

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