Synthesis, crystal structure and antimicrobial activity of deoxybenzoin derivatives from genistein.

Li HQ; Xue JY; Shi L; Gui SY; Zhu HL

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Synthesis, crystal structure and antimicrobial activity of deoxybenzoin derivatives from genistein.

机译：金雀异黄素中脱氧安息香衍生物的合成，晶体结构和抑菌活性。

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A series of deoxybenzoin derivatives from genistein were synthesized and their structures were elucidated by (1)H NMR, mass spectral data and micro analyses. The structures of 2, 7 and 10 were determined by single-crystal X-ray analysis. These obtained compounds were evaluated for their assayed antibacterial (Bacillus subtilis, Escherichia coli, Pseudomonas fluorescence and Staphylococcus aureus) and antifungal (Aspergillus niger, Candida albicans and Trichophyton rubrum) activities by MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide) method. Most compounds have displayed comparable antibacterial activity against bacterial. On the basis of the biological results, structure-activity relationships are discussed.

机译：合成了染料木黄酮的一系列脱氧安息香衍生物，并通过（1）NMR，质谱数据和显微分析阐明了它们的结构。通过单晶X射线分析确定2、7和10的结构。通过MTT（3-（4,5-methylthiazol-2-yl））-2,5-二苯基溴化四唑）法。大多数化合物对细菌显示出可比的抗菌活性。根据生物学结果，讨论了构效关系。

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《European Journal of Medicinal Chemistry: Chimie Therapeutique》 |2008年第3期|共6页
作者
Li HQ; Xue JY; Shi L; Gui SY; Zhu HL;
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正文语种 eng
中图分类医药、卫生;劳动卫生;
关键词
structure; derivatives; Genistein; Synthesis; 染料木黄酮;

机译：structure;derivatives;Genistein;Synthesis;染料木黄酮;

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1. Synthesis, crystal structure and antimicrobial activity of deoxybenzoin derivatives from genistein. [J] . Li HQ, Xue JY, Shi L, European Journal of Medicinal Chemistry: Chimie Therapeutique . 2008,第3期

机译：金雀异黄素中脱氧安息香衍生物的合成，晶体结构和抑菌活性。
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3. Synthesis, antimicrobial activity and chemotherapeutic potential of inorganic derivatives of 2-(4 '-thiazolyl)benzimidazole thiabendazole: X-ray crystal structures of [Cu(TBZH)(2)Cl]C1 center dot H2O center dot. EtOH and TBZH(2)NO(3) (TBZH = thiabend [J] . Devereux M, McCann M, Shea DO, Journal of Inorganic Biochemistry: An Interdisciplinary Journal . 2004,第6期

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6. Synthesis Crystal Structures and Antimicrobial and Antitumor Studies of Two Zinc(II) Complexes with Pyridine Thiazole Derivatives [O] . Zou Xun-Zhong, Feng An-Sheng, Zeng Fu-Ran, 2020

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7. Synthesis, antimicrobial activity and chemotherapeutic\ud potential of inorganic derivatives of\ud 2-(40-thiazolyl)benzimidazole{thiabendazole}: X-ray\ud crystal structures of [Cu(TBZH)2Cl]Cl • H2O • EtOH and\ud TBZH2NO3 (TBZH¼thiabendazole) [O] . Devereux, Michael, McCann, Malachy, O'Shea, Denis, 2004

机译：合成，抗菌活性及化学治疗 \ ud的无机衍生物的潜力 2-（40-噻唑基）苯并咪唑{噻苯达唑}：X射线\ ud [Cu（TBZH）2Cl] Cl•H2O•EtOH和\ ud的晶体结构 TBZH2NO3（TBZH¼噻苯达唑）

Synthesis, crystal structure and antimicrobial activity of deoxybenzoin derivatives from genistein.

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