Synthesis, characterization of copper(II), cobalt(II), nickel(II), zinc(II) and cadmium(II) complexes of (7-hydroxy-4-methyl-8-coumarinyl)glycine and a comparitive study of their microbial activities.

Gudasi KB; Patil MS; Vadavi RS

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Synthesis, characterization of copper(II), cobalt(II), nickel(II), zinc(II) and cadmium(II) complexes of (7-hydroxy-4-methyl-8-coumarinyl)glycine and a comparitive study of their microbial activities.

机译：（7-羟基-4-甲基-8-香豆基）甘氨酸的铜（II），钴（II），镍（II），锌（II）和镉（II）配合物的合成，表征及其比较研究微生物活动。

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A new Mannich base, [7-hydroxy-4-methyl-8-coumarinyl]glycine [MCGH(2)], has been prepared by the condensation of 7-hydroxy-4-methyl-coumarin with glycine and formaldehyde. Its conformational changes on complexation with transition metal ions [copper(II), cobalt(II), nickel(II), zinc(II) and cadmium(II)] have been studied on the basis of elemental analysis, conductivity measurements, spectral (infrared, (1)H NMR, electronic, EPR), magnetic and thermogravimetric studies. The infrared spectral studies of all the complexes reveal that the ligand has coordinated through -NH and two hydroxyl groups. The conductance data of the complexes suggest them to be non-electrolytes. Fluorescence property of the ligand and its metal complexes was studied and concluded that the ligand MCGH(2) can be a potential candidate for the determination of zinc(II) and cadmium(II) at room temperature by fluorimetric method. The antimicrobial activity of all the compounds was studied against Gram negative (Escherichia coli) and Gram positive (Bacillus cirroflagellosus) bacteria and fungi, Aspergillus niger and Candida albicans. It was observed that the coordination of metal ion has a pronounced effect on the microbial activities of the ligand. All the metal complexes have shown higher antimicrobial effect than the free ligand.

机译：一种新的曼尼希碱，[7-羟基-4-甲基-8-香豆基]甘氨酸[MCGH（2）]，是通过7-羟基-4-甲基香豆素与甘氨酸和甲醛的缩合制备的。在元素分析，电导率测量，光谱分析（光谱法）的基础上研究了其与过渡金属离子[铜（II），钴（II），镍（II），锌（II）和镉（II）]络合时的构象变化。红外，（1）H NMR，电子，EPR），磁和热重研究。所有配合物的红外光谱研究表明，配体已通过-NH和两个羟基进行配位。配合物的电导数据表明它们是非电解质。研究了配体及其金属配合物的荧光性质，得出的结论是，配体MCGH（2）可以在室温下通过荧光法测定锌（II）和镉（II）。研究了所有化合物对革兰氏阴性菌（大肠杆菌）和革兰氏阳性菌（环鞭毛芽孢杆菌），真菌，黑曲霉和白色念珠菌的抗菌活性。观察到金属离子的配位对配体的微生物活性具有显着影响。所有金属配合物均显示出比游离配体更高的抗菌作用。

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《European Journal of Medicinal Chemistry: Chimie Therapeutique》 |2008年第11期|共6页
作者
Gudasi KB; Patil MS; Vadavi RS;
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正文语种 eng
中图分类医药、卫生;劳动卫生;
关键词
Ligands; Zinc; Glycine; Cadmium; microbial; 配体; 锌; 甘氨酸; 镉;

机译：Ligands;Zinc;Glycine;Cadmium;microbial;配体;锌;甘氨酸;镉;

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Synthesis, characterization of copper(II), cobalt(II), nickel(II), zinc(II) and cadmium(II) complexes of (7-hydroxy-4-methyl-8-coumarinyl)glycine and a comparitive study of their microbial activities.

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