NSAIDs revisited: putative molecular basis of their interactions with peroxisome proliferator-activated gamma receptor (PPARgamma).

Romeiro NC; SantAnna CM; Lima LM; Fraga CA; Barreiro EJ

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NSAIDs revisited: putative molecular basis of their interactions with peroxisome proliferator-activated gamma receptor (PPARgamma).

机译：重新审视了NSAID：与过氧化物酶体增殖物激活的伽玛受体（PPARgamma）相互作用的推定分子基础。

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摘要

This paper describes molecular docking studies of a series of classical NSAIDs with PPARgamma receptor, which has been pointed as a new target for the design of anti-cancer and anti-inflammatory drugs, and has been found to be responsible for some of the already established pharmacological effects observed for marketed drugs. The results show the molecular basis of PPARgamma activation by non-selective COX inhibitors.

机译：本文介绍了一系列具有PPARγ受体的经典NSAID的分子对接研究，该研究已被认为是设计抗癌和抗炎药物的新目标，并被发现与某些已经建立的药物有关市售药物的药理作用。结果显示了非选择性COX抑制剂激活PPARγ的分子基础。

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来源
《European Journal of Medicinal Chemistry: Chimie Therapeutique》 |2008年第9期|共8页
作者
Romeiro NC; SantAnna CM; Lima LM; Fraga CA; Barreiro EJ;
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原文格式 PDF
正文语种 eng
中图分类医药、卫生;劳动卫生;
关键词
PPARgamma; receptor; Anti-Inflammatory Agents; Non-Steroidal; activate; Peroxisomes; 消炎药; 非甾类;

机译：PPARgamma;receptor;Anti-Inflammatory Agents;Non-Steroidal;activate;Peroxisomes;消炎药;非甾类;

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1. NSAIDs revisited: putative molecular basis of their interactions with peroxisome proliferator-activated gamma receptor (PPARgamma). [J] . Romeiro NC, SantAnna CM, Lima LM, European Journal of Medicinal Chemistry: Chimie Therapeutique . 2008,第9期

机译：重新审视了NSAID：与过氧化物酶体增殖物激活的伽玛受体（PPARgamma）相互作用的推定分子基础。
2. Selective peroxisome proliferator-activated receptor gamma (PPARgamma) modulation as a strategy for safer therapeutic PPARgamma activation. [J] . Higgins LS, Depaoli AM The American Journal of Clinical Nutrition: Official Journal of the American Society for Clinical Nutrition . 2010,第1期

机译：选择性过氧化物体增殖剂活化受体γ（PPARGAMMA）调制作为更安全的治疗性PPARGAMMA激活的策略。
3. Selective peroxisome proliferator-activated receptor gamma (PPARgamma) modulation as a strategy for safer therapeutic PPARgamma activation. [J] . Higgins LS, Depaoli AM The American Journal of Clinical Nutrition: Official Journal of the American Society for Clinical Nutrition . 2010,第1期

机译：选择性过氧化物体增殖剂活化受体γ（PPARGAMMA）调制作为更安全的治疗性PPARGAMMA激活的策略。
4. Molecular Docking Studies of Flavonoids of Noni Fruit (Morinda citrifolia L.) to Peroxisome Proliferator-Activated Receptor-Gamma (PPAR_γ) [C] . Fikry Awaluddin, Andrianopsyah Mas Jaya Putra, Supandi International Conference on Computation for Science and Technology . 2015

机译：非果（Morinda Citrifolia L.）黄酮类化合物对过氧化物增殖物激活受体 - γ（PPAR_γ）的分子对接研究
5. Peroxisome proliferator-activated receptor gamma (PPARgamma)-independent antitumor effect of thiazolidinediones. [D] . Wei, Shuo. 2010

机译：噻唑烷二酮类药物的过氧化物酶体增殖物激活受体γ（PPARgamma）独立的抗肿瘤作用。
6. A peroxisome proliferator-activated receptor ligand MCC-555 imparts anti-proliferative response in pancreatic cancer cells by PPARgamma-independent up-regulation of KLF4 [O] . Kyung-Won Min, Xiaobo Zhang, Temjenmongla Imchen, -1

机译：过氧化物体增殖物激活的受体配体MCC-555通过Ppargamma的胰腺癌细胞赋予胰腺癌细胞的抗增殖反应其KLF4独立的上调
7. Argan oil prevents down-regulation induced by endotoxin on liver fatty acid oxidation and gluconeogenesis and on peroxisome proliferator-activated receptor gamma coactivator-1 alpha, (PGC-1alpha), peroxisome proliferator-activated receptor gamma (PPARgamma) and estrogen related receptor alpha (ERRalpha) [O] . Kebbaj, Riad,, ANDREOLETTI, Pierre, El Hajj, Hammam,, 2015

机译：摩洛哥坚果油可防止内毒素引起的肝脏脂肪酸氧化和糖异生以及过氧化物酶体增殖物激活受体γcoactivator-1 alpha（PGC-1alpha），过氧化物酶体增殖物激活受体γ（PPARgamma）和雌激素相关受体α（ ERRalpha）

NSAIDs revisited: putative molecular basis of their interactions with peroxisome proliferator-activated gamma receptor (PPARgamma).

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