Azanonaboranes ((RNH(2))B(8)H(11)NHR) as possible new compounds for use in boron neutron capture therapy.

Bauer C; Gabel D; Dorfler U

首页> 外文期刊>European Journal of Medicinal Chemistry: Chimie Therapeutique >Azanonaboranes ((RNH(2))B(8)H(11)NHR) as possible new compounds for use in boron neutron capture therapy.

【24h】

Azanonaboranes ((RNH(2))B(8)H(11)NHR) as possible new compounds for use in boron neutron capture therapy.

机译：氮杂硼烷（（RNH（2））B（8）H（11）NHR）可能是用于硼中子俘获治疗的新化合物。

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

The synthesis and biological in vitro and in vivo activities of possible new compounds for Boron Neutron Capture Therapy (BNCT) are reported. The azanonaboranes of the type [(RNH(2))B(8)H(11)NHR] are water-soluble when hydrophilic groups are introduced. The reaction of B(9)H(13)SMe(2) with primary amines yields azanonaboranes. Five compounds with different numbers of hydroxypropyl groups have been isolated: [(HO(CH(2))(3)NH(2))B(8)H(11)NHCH(3)] (4), [(HO(CH(2))(3)NH(2))B(8)H(11)NH(CH(2))(3)OH] (2), [((HO(CH(2))(3))(2)NH)B(8)H(11)NHCH(3)] (6), [((HO(CH(2))(3))(2)NH)B(8)H(11)NH(CH(2))(3)OCH(3)] (11) and [((HO(CH(2))(3))(2)NH)B(8)H(11)NH(CH(2))(3)OH] (8). In vitro experiments as judged by cloning survival tests showed that two of the synthesised compounds are not toxic. The in vivo experiments were carried out with C3H/He mice bearing SCCVII tumours and C57 mice bearing B16 tumours. Compounds 2 and 6 have no particular affinity to any tissue, but are excluded from the brain.

机译：报道了用于硼中子俘获疗法（BNCT）的可能的新化合物的合成以及体外和体内的生物学活性。当引入亲水基团时，[（RNH（2））B（8）H（11）NHR]型的氮杂硼烷是水溶性的。 B（9）H（13）SMe（2）与伯胺的反应生成金刚烷硼烷。五个化合物具有不同数量的羟丙基已被分离：[[HO（CH（2））（3）NH（2））B（8）H（11）NHCH（3）]（4），[（HO（ CH（2））（3）NH（2））B（8）H（11）NH（CH（2））（3）OH]（2），[（（（HO（CH（2））（3））（2）NH）B（8）H（11）NHCH（3）]（6），[（（HO（CH（2））（3））（2）NH）B（8）H（11） NH（CH（2））（3）OCH（3）]（11）和[（（HO（CH（2））（3））（2）NH）B（8）H（11）NH（CH（ 2））（3）OH]（8）。通过克隆存活测试判断的体外实验表明，两种合成的化合物无毒。体内实验是用带有SCCVII肿瘤的C3H / He小鼠和带有B16肿瘤的C57小鼠进行的。化合物2和6对任何组织都没有特定的亲和力，但被排除在大脑之外。

著录项

来源
《European Journal of Medicinal Chemistry: Chimie Therapeutique》 |2002年第8期|共1页
作者
Bauer C; Gabel D; Dorfler U;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类医药、卫生;
关键词
No history of; History of (present illness); Boron Neutron Capture Therapy; 硼中子俘获疗法;

机译：No history of;History of (present illness);Boron Neutron Capture Therapy;硼中子俘获疗法;

相似文献

外文文献
中文文献
专利

1. Azanonaboranes ((RNH(2))B(8)H(11)NHR) as possible new compounds for use in boron neutron capture therapy. [J] . Bauer C, Gabel D, Dorfler U European Journal of Medicinal Chemistry: Chimie Therapeutique . 2002,第8期

机译：氮杂硼烷（（RNH（2））B（8）H（11）NHR）可能是用于硼中子俘获治疗的新化合物。
2. The chemistry of the azanonaborane cluster RNH2-B8H11NHR [Review] [J] . Gabel D., Bauer C., El-Zaria ME., Journal of Organometallic Chemistry . 2003,第1a2期

机译：氮杂硼烷簇RNH2-B8H11NHR的化学[综述]
3. 1H and 10B NMR and MRI investigation of boron- and gadolinium-boron compounds in boron neutron capture therapy. [J] . Bonora M, Corti M, Borsa F, Applied radiation and isotopes: including data, instrumentation and methods for use in agriculture, industry and medicine . 2011,第12期

机译：硼中子俘获治疗中硼和g硼化合物的1H和10B NMR和MRI研究。
4. Characterization of carriers for drug delivery in boron neutron capture therapy. Electron spin resonance study of nitroxide-containing liposomes [C] . G. Martini, S. Morandi, S. Rossi, Conference on Trends in Colloid and Interface Science . 2004

机译：硼中子捕获治疗中药物递送载体的表征。含氮氧化物脂质体的电子旋转共振研究
5. General Electric PETtrace cyclotron as a neutron source for boron neutron capture therapy. [D] . Bosko, Andrey. 2005

机译：通用电气PETtrace回旋加速器作为硼中子捕获疗法的中子源。
6. Pharmacokinetics in melanoma-bearing mice of 5-dihydroxyboryl-6-propyl-2-thiouracil (BPTU) a candidate compound for boron neutron capture therapy. [O] . R. Verrijk, I. J. Smolders, R. Huiskamp, 1994

机译：5-二羟基硼基-6-丙基-2-硫尿嘧啶（BPTU）（一种用于硼中子捕获疗法的候选化合物）在荷黑素瘤小鼠中的药代动力学。
7. Pharmacokinetics in melanoma-bearing mice of 5-dihydroxyboryl-6-propyl-2-thiouracil (BPTU), a candidate compound for boron neutron capture therapy. [O] . Verrijk, R., Smolders, I. J., Huiskamp, R., 1994

机译：5-二羟基硼基-6-丙基-2-硫尿嘧啶（BPTU）（一种用于硼中子捕获疗法的候选化合物）在荷黑素瘤小鼠中的药代动力学。
8. Micro-and Macroscopic Modelling of Boron Neutron Capture Therapy. Thermal NeutronFacility Design Phantom Calculations Microdosimetry [R] . Vroegindeweij, C. 1997

机译：硼中子俘获疗法的微观和宏观模型。热中子设备设计体模计算微测量

Azanonaboranes ((RNH(2))B(8)H(11)NHR) as possible new compounds for use in boron neutron capture therapy.

摘要

著录项

相似文献

相关主题

期刊订阅