Synthesis and characterization of binary and ternary complexes of diclofenac with a methyl-beta-CD and monoethanolamine and in vitro transdermal evaluation.

Mora MJ; Longhi MR; Granero GE

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Synthesis and characterization of binary and ternary complexes of diclofenac with a methyl-beta-CD and monoethanolamine and in vitro transdermal evaluation.

机译：双氯芬酸与甲基-β-CD和单乙醇胺的二元和三元复合物的合成，表征以及体外透皮评估。

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Here, we describe the chemical characterization of the inclusion complex between diclofenac (DCF) and methyl-beta-cyclodextrin (M-beta-CD) in the presence or absence of monoethanolamine (MEA). Several techniques were used to analyze the complex both in solution and in the solid state. Solubility of DCF was increased by the addition of M-beta-CD. However, the DCF solubility increase was more significant by the addition of M-beta-CD in the presence of MEA. In vitro permeation experiments through excised human skin revealed that DCF was enhanced by M-beta-CD. Nevertheless, further improvement in the flux and the permeability coefficient of DCF was obtained by the ternary system DCF-M-beta-CD-MEA.

机译：在这里，我们描述了在存在或不存在单乙醇胺（MEA）的情况下，双氯芬酸（DCF）和甲基-β-环糊精（M-β-CD）之间的包合物的化学表征。几种技术被用于分析溶液和固态的复合物。通过添加M-β-CD，DCF的溶解度增加。但是，通过在MEA存在下添加M-β-CD，DCF溶解度的增加更为显着。通过切除的人皮肤进行的体外渗透实验表明，M-β-CD增强了DCF。然而，通过三元体系DCF-M-β-CD-MEA获得了DCF的通量和磁导率系数的进一步改善。

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《European Journal of Medicinal Chemistry: Chimie Therapeutique》 |2010年第9期|共10页
作者
Mora MJ; Longhi MR; Granero GE;
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正文语种 eng
中图分类医药、卫生;劳动卫生;
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1. Synthesis and characterization of binary and ternary complexes of diclofenac with a methyl-beta-CD and monoethanolamine and in vitro transdermal evaluation. [J] . Mora MJ, Longhi MR, Granero GE European Journal of Medicinal Chemistry: Chimie Therapeutique . 2010,第9期

机译：双氯芬酸与甲基-β-CD和单乙醇胺的二元和三元复合物的合成，表征以及体外透皮评估。
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Synthesis and characterization of binary and ternary complexes of diclofenac with a methyl-beta-CD and monoethanolamine and in vitro transdermal evaluation.

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