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首页> 外文期刊>European Journal of Medicinal Chemistry: Chimie Therapeutique >Structural characterization and antibacterial activity against clinical isolates of Staphylococcus of N-phenylamide of monensin A and its 1:1 complexes with monovalent cations.
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Structural characterization and antibacterial activity against clinical isolates of Staphylococcus of N-phenylamide of monensin A and its 1:1 complexes with monovalent cations.

机译：对莫能菌素A的N-苯基酰胺葡萄球菌及其1：1单价阳离子复合物的临床分离株的结构表征和抗菌活性。

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摘要

The ability of N-phenylamide of monensin A (M-AM1) to form complexes with Li(+), Na(+) and K(+) cations is studied by ESI MS, (1)H and (13)C NMR, FT-IR spectroscopy and PM5 semi-empirical methods. ESI mass spectrometry indicates that M-AM1 forms complexes with the Li(+), Na(+) and K(+) cations of exclusively 1:1 stoichiometry which are stable up to cv = 90 V, and the formation of the complex with the Na(+) cation is strongly favoured. In the ESI MS spectra measured at cv = 110 V the fragmentation of the respective complexes, involving several dehydration steps, is observed. The spectroscopic studies show that the structures of M-AM1 and its complexes with Li(+), Na(+) and K(+) cations are stabilized by intramolecular hydrogen bonds in which OH groups are always involved. The CO amide group is shown to be engaged in the complexation process of each cation. However, there is a complex with K(+) cation in whose structure this CO amide group does not participate to a significant extent. The in vitro biological tests of M-AM1 amide have proved its good activity towards some strains of methicillin-susceptible Staphylococcus aureus (MSSA), methicillin-resistant S. aureus (MRSA) and methicillin-resistant Staphylococcus epidermidis (MRSE).
机译：ESI MS，（1）H和（13）C NMR研究了莫能菌素A（M-AM1）的N-苯基酰胺与Li（+），Na（+）和K（+）阳离子形成络合物的能力， FT-IR光谱和PM5半经验方法。 ESI质谱表明，M-AM1与仅化学计量为1：1的Li（+），Na（+）和K（+）阳离子形成络合物，在cv = 90 V时稳定，并且形成Na（+）阳离子受到强烈青睐。在cv = 110 V下测得的ESI MS光谱中，观察到各个配合物的断裂，包括几个脱水步骤。光谱研究表明，M-AM1及其与Li（+），Na（+）和K（+）阳离子形成的配合物的结构被分子内的氢键稳定，其中氢原子始终与OH基有关。显示CO酰胺基团参与每个阳离子的络合过程。但是，有一个带有K（+）阳离子的络合物，其CO酰胺基团的结构并未在很大程度上参与其中。 M-AM1酰胺的体外生物学测试已证明其对某些耐甲氧西林金黄色葡萄球菌（MSSA），耐甲氧西林金黄色葡萄球菌（MRSA）和耐甲氧西林表皮葡萄球菌（MRSE）的菌株具有良好的活性。

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