Recent methodologies toward the synthesis of valdecoxib: a potential 3,4-diarylisoxazolyl COX-II inhibitor.

Dadiboyena S; Nefzi A

首页> 外文期刊>European Journal of Medicinal Chemistry: Chimie Therapeutique >Recent methodologies toward the synthesis of valdecoxib: a potential 3,4-diarylisoxazolyl COX-II inhibitor.

【24h】

Recent methodologies toward the synthesis of valdecoxib: a potential 3,4-diarylisoxazolyl COX-II inhibitor.

机译：伐地考昔合成的最新方法：潜在的3,4-二芳基异恶唑基COX-II抑制剂。

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Non-steroidal anti-inflammatory drugs are widely used therapeutic agents in the treatment of inflammation, pain and fever. Cyclooxygenase catalyzes the initial step of biotransformation of arachidonic acid to prostanoids, and exist as three distinct isozymes; COX-I, COX-II and COX-III. Selective COX-II inhibitors are a class of potential anti-inflammatory, analgesic, and antipyretic drugs with reduced gastrointestinal (GI) side effects compared to nonselective inhibitors. 3,4-Diarylisoxazole scaffold is recurrently found in a wide variety of NSAIDs, protein kinase inhibitors, hypertensive agents, and estrogen receptor (ER) modulators. In the present review, we document on the recent synthetic strategies of 3,4-diarylisoxazolyl scaffolds of valdecoxib and its relevant structural analogues.

机译：非甾体抗炎药被广泛用于治疗炎症，疼痛和发烧。环氧合酶催化花生四烯酸生物转化为类前列腺素的起始步骤，并以三种不同的同工酶形式存在。 COX-I，COX-II和COX-III。选择性COX-II抑制剂是一类潜在的消炎，镇痛和解热药，与非选择性抑制剂相比，具有降低的胃肠道（GI）副作用。在各种NSAID，蛋白激酶抑制剂，高血压药和雌激素受体（ER）调节剂中经常发现3,4-二芳基异恶唑支架。在本综述中，我们记录了伐地昔布及其相关结构类似物的3,4-二芳基异恶唑基支架的最新合成策略。

著录项

来源
《European Journal of Medicinal Chemistry: Chimie Therapeutique》 |2010年第11期|共11页
作者
Dadiboyena S; Nefzi A;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类药学;
关键词

相似文献

外文文献
中文文献
专利

1. Recent methodologies toward the synthesis of valdecoxib: a potential 3,4-diarylisoxazolyl COX-II inhibitor. [J] . Dadiboyena S, Nefzi A European Journal of Medicinal Chemistry: Chimie Therapeutique . 2010,第11期

机译：伐地考昔合成的最新方法：潜在的3,4-二芳基异恶唑基COX-II抑制剂。
2. Recent methodologies toward the synthesis of valdecoxib: a potential 3,4-diarylisoxazolyl COX-II inhibitor. [J] . Dadiboyena S, Nefzi A European Journal of Medicinal Chemistry: Chimie Therapeutique . 2010,第11期

机译：最近涉及缬沙昔布的合成方法：潜在的3,4-二芳基唑唑基COX-II抑制剂。
3. Recent methodologies toward the synthesis of valdecoxib: a potential 3,4-diarylisoxazolyl COX-II inhibitor. [J] . Dadiboyena S, Nefzi A European Journal of Medicinal Chemistry: Chimie Therapeutique . 2010,第11期

机译：最近涉及缬沙昔布的合成方法：潜在的3,4-二芳基唑唑基COX-II抑制剂。
4. Synthesis and crystal structure of a new 2D coordination polymer Ce(3,4-pydc)_2·H_2O(3,4-pydc ＝ pyridine-3,4-dicarboxylate) [C] . Fenghua Bai, Liping Zhang, Haiquan Su, International Conference on Advanced Engineering Materials and Technology . 2011

机译：新的2D配位聚合物Ce（3,4-PYDC）_2·H_2O（3,4-PYDC =吡啶-3,4-二羧酸盐）的合成和晶体结构
5. Methodologies for the synthesis of 3,4-dioxypyrrole-based pi-conjugated materials. [D] . Arroyave Mondragon, Frank Antonio. 2011

机译：合成基于3,4-二氧吡咯的pi共轭材料的方法。
6. Recent Methodologies toward the Synthesis of Valdecoxib: A Potential 34-diarylisoxazolyl COX-2 Inhibitor [O] . Sureshbabu Dadiboyena, Adel Nefzi -1

机译：最近对valdecoxib合成的方法：潜在的34-二芳基唑唑基COX-2抑制剂
7. Complications of the Cox-II inhibitors parecoxib and valdecoxib after cardiac surgery [O] . Nussmeier N.A., Whelton A.A., Brown M.T. 2005

机译：心脏手术后Cox-II抑制剂parecoxib和valdecoxib的并发症

Recent methodologies toward the synthesis of valdecoxib: a potential 3,4-diarylisoxazolyl COX-II inhibitor.

摘要

著录项

相似文献

相关主题

期刊订阅