Synthesis of nitroimidazole derived oxazolidinones as antibacterial agents.

Varshney V; Mishra NN; Shukla PK; Sahu DP

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Synthesis of nitroimidazole derived oxazolidinones as antibacterial agents.

机译：硝基咪唑衍生的恶唑烷酮类作为抗菌剂的合成。

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A series of N-alkylated derivatives of nitroimidazolyl oxazolidinones 6a-i with various substituent at N-1 position of the nitroimidazole were synthesized and their in-vitro antibacterial activities were evaluated against several Gram-positive and Gram-negative bacteria. The 6a was found to be most potent compound in the series with MIC at 0.097 microg/mL against Bacillus cereus MTCC 430.). Both 6a and 6f did not exhibit any toxicity towards mammalian cell L929.

机译：合成了一系列在硝基咪唑的N-1位具有多个取代基的硝基咪唑基恶唑烷酮6a-i的N-烷基化衍生物，并评估了它们对几种革兰氏阳性和革兰氏阴性细菌的体外抗菌活性。发现6a是该系列中针对蜡样芽孢杆菌MTCC 430的最有效化合物，MIC为0.097 microg / mL。 6a和6f都没有表现出对哺乳动物细胞L929的任何毒性。

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《European Journal of Medicinal Chemistry: Chimie Therapeutique》 |2010年第2期|共6页
作者
Varshney V; Mishra NN; Shukla PK; Sahu DP;
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正文语种 eng
中图分类医药、卫生;劳动卫生;
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1. Synthesis of nitroimidazole derived oxazolidinones as antibacterial agents. [J] . Varshney V, Mishra NN, Shukla PK, European Journal of Medicinal Chemistry: Chimie Therapeutique . 2010,第2期

机译：硝基咪唑衍生的恶唑烷酮类作为抗菌剂的合成。
2. Structure-activity relationship (SAR) studies on oxazolidinone antibacterial agents. 3. Synthesis and evaluation of 5-thiocarbamate oxazolidinones. [J] . Tokuyama R, Takahashi Y, Tomita Y, Chemical and Pharmaceutical Bulletin . 2001,第4期

机译：恶唑烷酮抗菌剂的构效关系（SAR）研究。 3.5-硫代氨基甲酸酯恶唑烷酮的合成和评价。
3. Synthesis and in vitro activity of novel 1,2,4-triazolo[4,3-a]pyrimidine oxazolidinone antibacterial agents. Part II [J] . KheraM.K., CliffeI.A., PrakashO. Bioorganic and Medicinal Chemistry Letters . 2011,第18期

机译：新型1,2,4-三唑的合成和体外活性[4,3-A]嘧啶恶唑烷酮抗菌剂。第二部分
4. SCALABLE SYNTHESIS OF SUGAR-DERIVED SPIRO-OXAZOLIDINONES VIA CARBAMATE INTERMEDIATES [C] . Rolava E., Rodins V., Luginina J. International Carbohydrate Symposium . 2013

机译：通过氨基甲酸酯中间体可扩展合成糖衍生的螺氧氧唑烷酮
5. Design and synthesis of novel FtsZ-targeting antibacterial agents. [D] . Kelley, Cody. 2014

机译：设计和合成新型的靶向FtsZ的抗菌剂。
6. In vitro activities of U-100592 and U-100766 novel oxazolidinone antibacterial agents. [O] . G E Zurenko, B H Yagi, R D Schaadt, 1996

机译：新型恶唑烷酮抗菌剂U-100592和U-100766的体外活性。
7. Structure-Activity Relationship (SAR) Studies on Oxazolidinone Antibacterial Agents. 3. Synthesis and Evaluation of 5-Thiocarbamate Oxazolidinones. [O] . Ryukou TOKUYAMA, Yoshiei TAKAHASHI, Yayoi TOMITA, 2001

机译：恶唑烷酮抗菌剂的结构 - 活性关系（SAR）研究。 3. 5-硫代氨基甲酸盐氧酰胺的合成和评价。

Synthesis of nitroimidazole derived oxazolidinones as antibacterial agents.

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