Synthesis and evaluation of quinonoid compounds against tumor cell lines.

da Silva EN Jr; Cavalcanti BC; Guimaraes TT; Pinto Mdo C; Cabral IO; Pessoa C; Costa Lotufo LV; de Moraes MO; de Andrade CK; Dos Santos MR; de Simone CA; Goulart MO; Pinto AV

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Synthesis and evaluation of quinonoid compounds against tumor cell lines.

机译：醌类化合物对肿瘤细胞系的合成和评价。

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Thirty two compounds were synthesized in moderate to high yields and showed activity against cancer cells HL-60 (leukemia), MDA-MB435 (melanoma), HCT-8 (colon) and SF295 (central nervous system), with IC(50) below 2 muM for some compounds. The beta-lapachone-based 1,2,3-triazoles showed the best cytoxicity profile and emerge as promising anticancer prototypes. Insights about the reactive oxygen species (ROS) mechanism of anticancer action for some compounds were obtained by addition of 1-bromoheptane that deplete reduced glutathione (GSH) content and by using N-acetylcysteine that protects cells against apoptotic cellular death, as well by analysis of thiobarbituric acid reactive substances (TBARS) formation, and oxidative DNA damage after treatment detected by the comet assay with the bacterial enzymes formamidopyrimidine DNA-glycosylase (FPG) and endonuclease III (ENDOIII).

机译：以中等至高收率合成了32种化合物，它们显示出对癌细胞HL-60（白血病），MDA-MB435（黑色素瘤），HCT-8（结肠）和SF295（中枢神经系统）的活性，IC（50）低于某些化合物为2μM。基于β-拉帕酮的1,2,3-三唑显示出最佳的细胞毒性特征，并有望成为有希望的抗癌原型。通过添加1-溴庚烷以减少谷胱甘肽（GSH）含量，并使用N-乙酰半胱氨酸保护细胞免受凋亡性细胞死亡，从而获得对某些化合物的抗癌作用的活性氧（ROS）机制的见解，以及通过分析彗星试验检测到的细菌细菌甲酰胺嘧啶DNA-糖基化酶（FPG）和内切核酸酶III（ENDOIII）对硫代巴比妥酸反应性物质（TBARS）的形成和DNA氧化后DNA损伤的影响。

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《European Journal of Medicinal Chemistry: Chimie Therapeutique》 |2011年第1期|共12页
作者
da Silva EN Jr; Cavalcanti BC; Guimaraes TT; Pinto Mdo C; Cabral IO; Pessoa C; Costa Lotufo LV; de Moraes MO; de Andrade CK; Dos Santos MR; de Simone CA; Goulart MO; Pinto AV;
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1. Synthesis and evaluation of quinonoid compounds against tumor cell lines. [J] . da Silva EN Jr, Cavalcanti BC, Guimaraes TT, European Journal of Medicinal Chemistry: Chimie Therapeutique . 2011,第1期

机译：醌类化合物对肿瘤细胞系的合成和评价。
2. New synthesis of two tridentate bipyrazolic compounds and their cytotoxic activity tumor cell lines. [J] . Kodadi ME, Benamar M, Ibrahim B, Natural product research . 2007,第11期

机译：两种三齿联吡唑化合物的新合成及其具有细胞毒性的肿瘤细胞系。
3. Effect of modification of 6-((aminoalkyl)amino)-7H-benzo(e)-perimidin-7-ones on their cytotoxic activity toward sensitive and multidrug resistant tumor cell lines. Synthesis and biological evaluation. [J] . Dzieduszycka M, Martelli S, Arciemiuk M, Bioorganic and medicinal chemistry . 2002,第4期

机译：修饰6-（（（氨基烷基）氨基）-7H-苯并（e）-perimidin-7-ones对敏感和多药耐药肿瘤细胞系细胞毒性的影响。合成和生物学评估。
4. ANGIOGENESIS AND LYMPHANGIOGENESIS IN TISSUES DEVELOPED IN NUDE MICE XENOGRAFTED WITH TWO CANINE MAMMARY GLAND TUMOR CELL LINES. [C] . Soojung Lee, Takayuki Nakagawa, Nozomi Miyajima, Annual Conference of the Veterinary Cancer Society . 2009

机译：裸鼠卵乳腺肿瘤细胞系裸鼠生殖器中血管生成和淋巴管发生。
5. The Role of miR-100 in Glioblastoma Tumor Initiating Cells and the related Tumor Lines. [D] . Alrfaei, Bahauddeen M. 2013

机译：miR-100在胶质母细胞瘤肿瘤起始细胞和相关肿瘤细胞系中的作用。
6. Synthesis biological evaluation and molecular modeling studies on novel quinonoid inhibitors of CDC25 phosphatases [O] . Emilie Evain-Bana, Lucie Schiavo, Christophe Bour, 2017

机译：CDC25磷酸酶新型醌类抑制剂的合成生物学评价和分子模型研究
7. Synthesis and evaluation of quinonoid compounds against tumor cell lines [O] . da Silva Eufrânio N., Cavalcanti Bruno C., Guimarães Tiago T., 2011

机译：喹诺酮类化合物抗肿瘤细胞系的合成与评价
8. Synthesis and Electrical Properties of Benzimidazoles and Heterocyclic Quinonoid Compounds [R] . Obermayer, A. S., Nichols, L. D., Hannauer, C. E., 1964

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Synthesis and evaluation of quinonoid compounds against tumor cell lines.

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