Synthesis and characterization of polyester conjugates of ciprofloxacin.

Sobczak M

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Synthesis and characterization of polyester conjugates of ciprofloxacin.

机译：环丙沙星聚酯共轭物的合成与表征。

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Two-, three-, four and six-arm, star-shaped poly(epsilon-caprolactone) and polylactide homopolymers were synthesized via ring-opening polymerization of cyclic esters in the presence of glycerol, penthaerythritol, dipentaerythritol and poly(ethylene glycol) as initiators and stannous octoate as a catalyst. Thus obtained oligomers were successfully used in the synthesis of novel polyester conjugates of ciprofloxacin. The structures of the polymers and conjugates were determined by means of GPC, MALDI-TOF MS, NMR and IR studies. The in vitro release of ciprofloxacin from obtained conjugates was investigated.

机译：通过在甘油，季戊四醇，二季戊四醇和聚乙二醇为引发剂和辛酸亚锡作为催化剂。如此获得的低聚物已成功用于合成环丙沙星的新型聚酯共轭物。聚合物和结合物的结构是通过GPC，MALDI-TOF MS，NMR和IR研究确定的。研究了从获得的结合物中的环丙沙星的体外释放。

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《European Journal of Medicinal Chemistry: Chimie Therapeutique》 |2010年第9期|共6页
作者
Sobczak M;
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正文语种 eng
中图分类医药、卫生;劳动卫生;
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机译：环丙沙星聚酯共轭物的合成与表征。
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Synthesis and characterization of polyester conjugates of ciprofloxacin.

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