Synthesis, structure and DNA cleavage studies of coumarin analogues of tetrahydroisoquinoline and protoberberine alkaloids.

Jadhav VB; Nayak SK; Row TN; Kulkarni MV

首页> 外文期刊>European Journal of Medicinal Chemistry: Chimie Therapeutique >Synthesis, structure and DNA cleavage studies of coumarin analogues of tetrahydroisoquinoline and protoberberine alkaloids.

【24h】

Synthesis, structure and DNA cleavage studies of coumarin analogues of tetrahydroisoquinoline and protoberberine alkaloids.

机译：四氢异喹啉和原小ber碱生物碱香豆素类似物的合成，结构和DNA裂解研究。

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Novel molecular matrices have been derived from coumarin-4-acetic acids and beta-phenylethylamines using the Bischler-Napieralski protocol which has led to the synthesis of analogues of tetrahydropapaverine in which the dimethoxybenzene moiety has been replaced by substituted coumarins. One carbon homologation has led to cyclization at the C3 position of coumarin generating the protoberberine skeleton. Structures have been confirmed by diffraction studies. The results showed that compounds 6e, 6f, 7e and 7f were found to be very effective against DNA samples of Gram positive bacterium Staphylococcus aureus and fungus Aspergillus niger.

机译：使用Bischler-Napieralski协议已从香豆素-4-乙酸和β-苯乙胺衍生出新的分子基质，该协议已合成四氢罂粟碱的类似物，其中二甲氧基苯部分已被取代的香豆素取代。一种碳同源性导致香豆素的C3位置环化，生成原小ber碱骨架。通过衍射研究已经确认了结构。结果表明，发现化合物6e，6f，7e和7f对革兰氏阳性细菌金黄色葡萄球菌和真菌黑曲霉的DNA样品非常有效。

著录项

来源
《European Journal of Medicinal Chemistry: Chimie Therapeutique》 |2010年第9期|共6页
作者
Jadhav VB; Nayak SK; Row TN; Kulkarni MV;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类医药、卫生;劳动卫生;
关键词

相似文献

外文文献
中文文献
专利

1. Synthesis, structure and DNA cleavage studies of coumarin analogues of tetrahydroisoquinoline and protoberberine alkaloids. [J] . Jadhav VB, Nayak SK, Row TN, European Journal of Medicinal Chemistry: Chimie Therapeutique . 2010,第9期

机译：四氢异喹啉和原小ber碱生物碱香豆素类似物的合成，结构和DNA裂解研究。
2. Synthesis and evaluation of novel coumarin-oxime ethers as potential anti-tubercular agents: Their DNA cleavage ability and BSA interaction study [J] . Reddy Dinesh S., Kongot Manasa, Netalkar Sandeep P., European Journal of Medicinal Chemistry: Chimie Therapeutique . 2018,第期

机译：新型香豆素 - 肟醚作为潜在抗结核剂的合成与评价：其DNA切割能力和BSA相互作用研究
3. Microwave-assisted synthesis of new fluorinated coumarin-pyrimidine hybrids as potent anticancer agents, their DNA cleavage and X-ray crystal studies [J] . Hosamani Kallappa. M., Reddy Dinesh S., Devarajegowda Hirihalli. C. RSC Advances . 2015,第15期

机译：微波辅助合成新的氟化香豆素-嘧啶杂种作为有效的抗癌剂，其DNA裂解和X射线晶体研究
4. Carboranyl Tetrahydroisoquinolines. Synthesis and the X-ray Structural Study of 1-(o-Carboran-l-ylmethyl)-l,2,3,4-Tetrahydroisoquinolines [C] . Jong Dae Lee, Chai-Ho Lee, Seung-Hoon Lee, Workshop on the utilization of research reactors . 2001

机译：碳硼烷基四氢异喹啉。 1-（邻-甲硼烷-1-基甲基）-1,2,3,4-四氢异喹啉的合成及X射线结构研究
5. DNA-binding properties and topoisomerase-I inhibitory activities of natural and synthesized protoberberine alkaloids. [D] . Qin, Yong. 2007

机译：天然和合成的原小ber碱生物碱的DNA结合特性和拓扑异构酶-I抑制活性。
6. Microwave assisted synthesis of coumarin-purine derivatives: An approach to in vitro anti-oxidant DNA cleavage crystal structure DFT studies and Hirshfeld surface analysis [O] . Sumitra N. Mangasuli, Kallappa M. Hosamani, Praveen B. Managutti 2019

机译：微波辅助合成香豆素-嘌呤衍生物：体外抗氧化剂DNA裂解晶体结构DFT研究和Hirshfeld表面分析的方法
7. Synthesis, characterization, spectrophotometric and electrochemistry studies, and DNA cleavage of copper(II) complexes of a new azacrown bis-macrocycle and its mono-cyclic analogue [O] . Khoramdareh Zahra Kalantari, Hosseini-Yazdi Seyed Abolfazl, Spingler Bernhard, 2014

机译：新型氮杂双环大环及其单环类似物的铜（II）配合物的合成，表征，分光光度法和电化学研究
8. Structure-Activity Study of Paracetamol Analogues: Inhibition of Replicative DNASynthesis in V79 Chinese Hamster Cells [R] . Richard, A. M., Hongslo, J. K., Boone, P. F., 1991

机译：对乙酰氨基酚类似物的结构 - 活性研究：V79中国仓鼠细胞中复制DNa合成的抑制

Synthesis, structure and DNA cleavage studies of coumarin analogues of tetrahydroisoquinoline and protoberberine alkaloids.

摘要

著录项

相似文献

相关主题

期刊订阅