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首页> 外文期刊>European Journal of Medicinal Chemistry: Chimie Therapeutique >Synthesis, characterization and antimicrobial studies of some new pyrazole incorporated imidazole derivatives.
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Synthesis, characterization and antimicrobial studies of some new pyrazole incorporated imidazole derivatives.

机译：一些新型吡唑并入咪唑衍生物的合成，表征和抗菌研究。

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摘要

In the present study two series of novel imidazole derivatives containing substituted pyrazole moiety (3a-d and 5a-j) were synthesized. The first series were synthesized by the reaction of 3-aryl-1H-pyrazole-4-carbaldehyde thiosemicarbazones (2a-d) with DMAD and the second series by the reaction of 3-aryl-1H-pyrazole-4-carbaldehydes (1a-e) with 1,2-diketones (4a,b) in the presence of ammonium acetate. Structures of newly synthesized compounds were characterized by spectral studies. New compounds were screened for antifungal and antibacterial activities. Among the synthesized compounds, compound 3c was found to be potent antimicrobial agent. The acute oral toxicity study for the compound 3c was carried out and the experimental studies revealed that compound 3c is safe up to 3000 mg/kg and no death of animals were recorded.
机译：在本研究中，合成了两个含有取代的吡唑部分（3a-d和5a-j）的新型咪唑衍生物。第一个系列是通过3-芳基-1H-吡唑-4-甲醛甲醛半缩酮（2a-d）与DMAD反应合成的，第二个系列是通过3-芳基-1H-吡唑-4-甲醛（1a- e）在乙酸铵存在下与1,2-二酮（4a，b）。通过光谱研究表征了新合成的化合物的结构。筛选新化合物的抗真菌和抗菌活性。在合成的化合物中，发现化合物3c是有效的抗菌剂。进行了化合物3c的急性口服毒性研究，实验研究表明，化合物3c高达3000 mg / kg是安全的，没有动物死亡的记录。

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