Synthesis and crystal structure of two new dinuclear cobalt(II) complexes interaction with HeLa cells.

Gao EJ; Gao XN; Guan F; Zhu MC; Liu L; Zhang M; Zhang YX; Wang Y; Wen Z; Zhang Y; Liang Q

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Synthesis and crystal structure of two new dinuclear cobalt(II) complexes interaction with HeLa cells.

机译：两种新型双核钴（II）配合物与HeLa细胞相互作用的合成和晶体结构。

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Two novel dinuclear complexes [Co(2)(L)(2)(phen)(2)2H(2)O](n) (1), [Co(2)(L)(2)(bipy)(2)](n) (2) (where phen=1,10-phenanthroline, bipy=2,2'-bipyridine, and L=biphenyl-2,4'-dicarboxylic acid) have been synthesized and characterized using IR, (1)H NMR, element analysis and single-crystal X-ray diffractometry. The binding of the complexes with HC-DNA (HeLa cells DNA, which was extracted by ourselves) was investigated by fluorescence spectrum. The experimental results show that the two complexes have the ability to bind with extracted HC-DNA. Gel electrophoresis assay demonstrates the ability of the complexes to cleave the extracted HC-DNA. The complexes exhibit a higher cytotoxicity against tumor cells as against normal cells in vitro. Further more, the apoptotic tests indicate that the complexes have an apoptotic effect on HeLa cells.

机译：两个新颖的双核配合物[Co（2）（L）（2）（phen）（2）2H（2）O]（n）（1），[Co（2）（L）（2）（bipy）（2 ）]（n）（2）（其中phen = 1,10-菲咯啉，bipy = 2,2'-联吡啶和L = biphenyl-2,4'-二羧酸）已经合成并使用IR表征，（1 1 H NMR，元素分析和单晶X射线衍射。通过荧光光谱研究了复合物与HC-DNA（HeLa细胞DNA，由我们自己提取）的结合。实验结果表明，两种复合物均具有与提取的HC-DNA结合的能力。凝胶电泳分析证明了复合物裂解提取的HC-DNA的能力。该复合物在体外对肿瘤细胞显示出比正常细胞更高的细胞毒性。此外，凋亡测试表明该复合物对HeLa细胞具有凋亡作用。

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《European Journal of Medicinal Chemistry: Chimie Therapeutique》 |2011年第1期|共8页
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Gao EJ; Gao XN; Guan F; Zhu MC; Liu L; Zhang M; Zhang YX; Wang Y; Wen Z; Zhang Y; Liang Q;
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Synthesis and crystal structure of two new dinuclear cobalt(II) complexes interaction with HeLa cells.

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