Synthesis, DNA-binding and topoisomerase inhibitory activity of ruthenium(II) polypyridyl complexes.

Du KJ; Wang JQ; Kou JF; Li GY; Wang LL; Chao H; Ji LN

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Synthesis, DNA-binding and topoisomerase inhibitory activity of ruthenium(II) polypyridyl complexes.

机译：钌（II）聚吡啶基配合物的合成，DNA结合和拓扑异构酶抑制活性。

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Two ruthenium(II) complexes [Ru(bpy)(2)(bfipH)](2+) (1) and [Ru(phen)(2)(bfipH)](2+) (2) have been synthesized and characterized. The DNA-binding behaviors of complexes were studied by using spectroscopic and viscosity measurements. Results suggested that the two complexes bind to DNA in an intercalative mode. Complexes 1 and 2 can efficiently photocleave pBR322 DNA in vitro under irradiation, singlet oxygen ((1)O(2)) was proved to contribute to the DNA photocleavage process. Topoisomerase inhibition and DNA strand passage assay confirmed that two Ru(II) complexes acted as efficient dual inhibitors of topoisomerases I and II. In MTT cytotoxicity studies, two Ru(II) complexes exhibited antitumor activity against BEL-7402, HeLa, MCF-7 tumor cells. The AO/EB staining assay indicated that Ru(II) complexes could induce the apoptosis of HeLa cells.

机译：已合成并表征了两种钌（II）配合物[Ru（bpy）（2）（bfipH）]（2+）（1）和[Ru（phen）（2）（bfipH）]（2+）（2）。通过光谱和粘度测量研究了复合物的DNA结合行为。结果表明这两种复合物以插入模式与DNA结合。配合物1和2可以有效地体外照射下光解pBR322 DNA，单重态氧（（1）O（2））被证明有助于DNA的光切割过程。拓扑异构酶抑制和DNA链传递测定证实，两种Ru（II）复合物可作为拓扑异构酶I和II的有效双重抑制剂。在MTT细胞毒性研究中，两种Ru（II）配合物对BEL-7402，HeLa，MCF-7肿瘤细胞表现出抗肿瘤活性。 AO / EB染色检测结果表明，Ru（II）复合物可诱导HeLa细胞凋亡。

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《European Journal of Medicinal Chemistry: Chimie Therapeutique》 |2011年第4期|共10页
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Du KJ; Wang JQ; Kou JF; Li GY; Wang LL; Chao H; Ji LN;
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1. Synthesis, DNA-binding and topoisomerase inhibitory activity of ruthenium(II) polypyridyl complexes. [J] . Du KJ, Wang JQ, Kou JF, European Journal of Medicinal Chemistry: Chimie Therapeutique . 2011,第4期

机译：钌（II）聚吡啶基配合物的合成，DNA结合和拓扑异构酶抑制活性。
2. Synthesis and Characterisation of Ru~(II) Polypyridyl Complexes: DNA-Binding, Photocleavage, and Topoisomerase I and II Inhibitory Activity [J] . Xiaojun He, Guang Yang, Xiaonan Sun Australian Journal of Chemistry: A Journal for the Publication of Original Research in All Branches of Chemistry . 2013,第11期

机译：Ru〜（II）多吡啶基配合物的合成与表征：DNA结合，光裂解以及拓扑异构酶I和II的抑制活性
3. Synthesis, DNA-binding, photocleavage, cytotoxicity and antioxidant activity of ruthenium (II) polypyridyl complexes. [J] . Liu YJ, Zeng CH, Huang HL, European Journal of Medicinal Chemistry: Chimie Therapeutique . 2010,第2期

机译：钌（II）聚吡啶配合物的合成，DNA结合，光裂解，细胞毒性和抗氧化活性。
4. Molecular Design, Synthesis and Inhibitory Activity of New Photosystem II Inhibitors [C] . Liu Huayin, Sha Yinlin, Tan Huifen, 9th Japan-China Symposium on Pesticide Science October 26-28, 1998 Tian Jin China . 1998

机译：新的Photosystem II抑制剂的分子设计，合成和抑制活性
5. Photochemistry of group 8 metal complexes of type [M(bpy)2 cyanogen] (M = iron, ruthenium). Photosynthesis of heteroleptic iron(II) compounds and photoionization of ruthenium(II) compounds, or, Photoassisted synthesis of heteroleptic iron(II) compounds and photoionization of ruthenium(II) complexes. [D] . Turner, David Benjamin. 2009

机译：[M（bpy）2氰基]类型的第8组金属配合物的光化学（M =铁，钌）。杂合铁（II）化合物的光合作用和钌（II）化合物的光电离，或者杂合铁（II）化合物的光辅助合成和钌（II）配合物的光电离。
6. Antibacterial Activity of 2-Picolyl-polypyridyl-Based Ruthenium (II/III) Complexes on Non-Drug-Resistant and Drug-Resistant Bacteria [O] . James T. P. Matshwele, Sebusi Odisitse, Daphne Mapolelo, 2021

机译：2-吡啶基聚吡啶基钌（II / III）复合物对非耐药性和耐药细菌的抗菌活性
7. A New Strategy for Improvement of Photophysical Properties in Ruthenium(II) Polypyridyl Complexes. Synthesis, Photophysical and Electrochemical Characterisation of Six Mononuclear Ruthenium(II) Bisterpyridine Type Complexes [O] . Abrahamsson, Maria, Wolpher, Henriette, Johansson, Olof, 2005

机译：提高钌（II）多吡啶配合物光物理性质的新策略。六种单核钌（II）Bisterpyridine型配合物的合成，光物理和电化学表征

Synthesis, DNA-binding and topoisomerase inhibitory activity of ruthenium(II) polypyridyl complexes.

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