Design of novel aminopyrrolidine factor Xa inhibitors from a screening hit.

Zbinden KG; Anselm L; Banner DW; Benz J; Blasco F; Decoret G; Himber J; Kuhn B; Panday N; Ricklin F; Risch P; Schlatter D; Stahl M; Thomi S; Unger R; Haap W

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Design of novel aminopyrrolidine factor Xa inhibitors from a screening hit.

机译：根据筛选结果设计新型氨基吡咯烷因子Xa抑制剂。

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Starting from a hit identified by focused screening, 3-aminopyrrolidine factor Xa inhibitors were designed. The binding mode as determined by X-ray structural analysis as well as the pharmacokinetic behaviour of selected compounds is discussed.

机译：从通过重点筛选确定的命中开始，设计了3-氨基吡咯烷因子Xa抑制剂。讨论了通过X射线结构分析确定的结合模式以及所选化合物的药代动力学行为。

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《European Journal of Medicinal Chemistry: Chimie Therapeutique》 |2009年第7期|共9页
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Zbinden KG; Anselm L; Banner DW; Benz J; Blasco F; Decoret G; Himber J; Kuhn B; Panday N; Ricklin F; Risch P; Schlatter D; Stahl M; Thomi S; Unger R; Haap W;
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正文语种 eng
中图分类药学;
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1. Design of novel aminopyrrolidine factor Xa inhibitors from a screening hit. [J] . Zbinden KG, Anselm L, Banner DW, European Journal of Medicinal Chemistry: Chimie Therapeutique . 2009,第7期

机译：根据筛选结果设计新型氨基吡咯烷因子Xa抑制剂。
2. Pyrrolidine-constrained phenethylamines: The design of potent, selective, and pharmacologically efficacious dipeptidyl peptidase IV (DPP4) inhibitors from a lead-like screening hit. [J] . Backes BJ, Longenecker K, Hamilton GL, Bioorganic and Medicinal Chemistry Letters . 2007,第7期

机译：吡咯烷约束的苯乙胺：一种有效的，选择性的和药理学有效的二肽基肽酶IV（DPP4）抑制剂的设计，该抑制剂来自铅样筛选命中者。
3. Pharmacophore Identification,in Silico Screening,and Virtual Library Design for Inhibitors of the Human Factor Xa [J] . Eva M.Krovat, Karin H.Friihwirth, Thierry Langer Journal of chemical information and modeling . 2005,第1期

机译：药效基团鉴定，计算机筛选以及人因子Xa抑制剂的虚拟文库设计
4. Assessment of the efficacy of tissue factor pathway inhibitor (TFPI) immobilized on glass slides to inhibit factor Xa under flow conditions [C] . Chandiwal, A., Mast, . 2002

机译：评估流动条件下固定在载玻片上的组织因子途径抑制剂（TFPI）抑制Xa因子的功效
5. Validating dynamic pharmacophore based virtual screening and *computational insight into human blood coagulation factor Xa subsites [D] . Singh, Narender 2007

机译：验证基于动态药效团的虚拟筛选和*对人类凝血因子Xa子位点的计算洞察力
6. Theoretical Study of Molecular Structure and Physicochemical Properties of Novel Factor Xa Inhibitors and Dual Factor Xa and Factor IIa Inhibitors [O] . Milan Remko, Anna Remková, Ria Broer 2016

机译：新型因子Xa抑制剂和双因子Xa和因子IIa抑制剂的分子结构和理化性质的理论研究
7. Theoretical Study of Molecular Structure and Physicochemical Properties of Novel Factor Xa Inhibitors and Dual Factor Xa and Factor IIa Inhibitors [O] . Milan Remko, Anna Remková, Ria Broer 2016

机译：新型因子Xa抑制剂和双因子Xa和因子IIa抑制剂的分子结构和理化性质的理论研究

Design of novel aminopyrrolidine factor Xa inhibitors from a screening hit.

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