• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>European Journal of Medicinal Chemistry: Chimie Therapeutique >Ruthenium (II) phosphine/picolinate complexes as antimycobacterial agents.
【24h】

Ruthenium (II) phosphine/picolinate complexes as antimycobacterial agents.

机译：钌（II）膦/吡啶甲酸络合物作为抗分枝杆菌剂。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The synthesis, characterization and the anti-Mycobacterium tuberculosis (MTB) activities of three ruthenium complexes containing the 2-pyridinecarboxylic acid anion (picolinate), with formulae cis- [Ru(pic)(dppm)(2)]PF(6) (1), cis- [Ru(pic)(dppe)(2)]PF(6) (2) and [Ru(pic)(2)(PPh(3))(2)] (3) [pic=2-pyridinecarboxylate; dppm=bis(diphenylphosphino)methane; dppe=1,2-bis(diphenylphosphino)ethane; PPh(3)=triphenylphosphine] are reported in this article. The complexes were characterized by elemental analysis, spectroscopic and electrochemical techniques. Their in vitro antimycobacterial activity was determinated as the Minimum Inhibitory Concentration (MIC) for MTB cell growth, measured by the REMA method. The best MICs were found for complexes (1) and (2), with values of 0.78 and 0.26 microg/mL, respectively. The results are comparable to or better than "first line" or "second line" drugs commonly used in the treatment of TB.
机译：三种含有2-吡啶羧酸阴离子（吡啶甲酸）的钌配合物的合成，表征和抗结核分枝杆菌（MTB）活性，分子式为cis- [Ru（pic）（dppm）（2）] PF（6）（ 1），顺式-[Ru（pic）（dppe）（2）] PF（6）（2）和[Ru（pic）（2）（PPh（3））（2）]（3）[pic = 2 -吡啶羧酸盐; dppm ＝双（二苯基膦基）甲烷; dppe = 1,2-双（二苯基膦基）乙烷; PPh（3）= triphenylphosphine]报道在这篇文章中。配合物通过元素分析，光谱学和电化学技术进行表征。他们的体外抗分枝杆菌活性被确定为MTA细胞生长的最小抑制浓度（MIC），通过REMA方法测量。配合物（1）和（2）的最佳MIC值分别为0.78和0.26 microg / mL。结果与通常用于治疗结核病的“一线”或“二线”药物相当或更好。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号