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首页> 外文期刊>European Journal of Medicinal Chemistry: Chimie Therapeutique >Synthesis, structure and in vitro antibacterial activities of new hybrid disinfectants quaternary ammonium compounds: pyridinium and quinolinium stilbene benzenesulfonates.
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Synthesis, structure and in vitro antibacterial activities of new hybrid disinfectants quaternary ammonium compounds: pyridinium and quinolinium stilbene benzenesulfonates.

机译：新型杂化消毒剂季铵化合物：吡啶鎓和喹啉鎓二苯乙烯苯磺酸盐的合成，结构和体外抗菌活性。

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摘要

The series of pyridinium (1-10) and quinolinium (11-20) stilbene benzenesulfonates have been synthesized and their structures were investigated by UV-vis, FT-IR and (1)H NMR spectroscopy. In addition, compound 5 was also determined by single crystal X-ray diffraction technique. The antibacterial activity of the synthesized compounds against both gram-positive and gram-negative bacteria has been determined. The quinolinium derivatives exhibited two very potent characteristic activities, namely, (i) specific activity to Methicillin-Resistant Staphylococcus aureus and (ii) with broad band spectrum activity. Compounds 11, 13 and 14 are the most active showing broad spectrum antibacterial activity against gram-positive (Methicillin-Resistant S. aureus, S. aureus, Bacillus subtilis, Vancomycin-Resistant Enterococcus faecalis and E. faecalis) and gram-negative bacterium (Shigella sonnei). The MICs of these compounds were found to be better than that of Benzalkonium chloride (BZK), the commercially used disinfectant.
机译：合成了一系列吡啶鎓（1-10）和喹啉鎓（11-20）二苯乙烯苯磺酸盐，并通过紫外可见光谱，傅立叶变换红外光谱和（1）H NMR光谱研究了它们的结构。另外，化合物5也通过单晶X射线衍射技术测定。已经确定了合成的化合物对革兰氏阳性和革兰氏阴性细菌的抗菌活性。喹啉鎓衍生物表现出两个非常有效的特征活性，即（i）对耐甲氧西林的金黄色葡萄球菌的比活性和（ii）具有宽带光谱活性。化合物11、13和14对革兰氏阳性菌（耐甲氧西林金黄色葡萄球菌，金黄色葡萄球菌，枯草芽孢杆菌，耐万古霉素肠球菌和粪肠球菌）和革兰氏阴性细菌（革兰氏阴性）的活性最高，显示出广谱抗菌活性。志贺氏菌（Shigella sonnei）。发现这些化合物的MIC优于市售消毒剂苯扎氯铵（BZK）。

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