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首页> 外文期刊>European Journal of Veterinary Pathology >Classification of malignant lymphoma in domestic animals: history and conceptual evolution.
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Classification of malignant lymphoma in domestic animals: history and conceptual evolution.

机译：家畜恶性淋巴瘤的分类：历史和概念演变。

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摘要

Malignant lymphomas (ML) are an heterogeneous group of neoplasms with variable morphology, diverse clinical presentations and variable prognosis and treatment. For these reasons, numerous attempts have been made both in human and veterinary oncology, in order to establish rational classifications of these tumors. There were based upon the contemporary knowledges of normal blood cell and precursor morphology. Developments have occured in parallel with the progress in our knowledge as cytological methods of identification improved. Because of the numerous similarities between animal and human ML most of the proposed animal ML classifications were adapted from the human schemes. Nevertheless, due to major differences between human and animal lymphomas excepted for some categories of tumours the clinical value of these classifications remains to be accuratly demonstrated. The revised European American lymphoma classification (REAL) which is now accepted worldwide by clinicians and pathologists, provides for extensive subdivision of the ML based on both morphology and immunophenotype and on cytogenesis for some subtypes. The neoplasms are classified as distinct entities in regard to histogenic derivation and biological behaviour. The sophistication for tumor management in veterinary medicine and the growing availability of more immunological markers in animal hematology, prompted us to propose the REAL classification for animal oncology. The proof, however of relevance of this ML classification will depend on large clinico-pathological studies involving both clinicians and pathologists.
机译：恶性淋巴瘤（ML）是一组异质性肿瘤，其形态各异，临床表现多样，预后和治疗也不同。由于这些原因，为了建立这些肿瘤的合理分类，已经在人和兽医肿瘤学方面进行了许多尝试。基于当代关于正常血细胞和前体形态的知识。随着细胞学鉴定方法的改进，发展与我们的知识发展同时发生。由于动物和人类ML之间有许多相似之处，因此大多数拟议的动物ML分类都是根据人类计划改编的。但是，由于人类和动物淋巴瘤之间的主要区别（除了某些类别的肿瘤），这些分类的临床价值仍有待准确证明。修订后的欧洲淋巴瘤分类（REAL）目前已为全球临床医生和病理学家所接受，它基于形态学和免疫表型以及某些亚型的细胞生成，为ML提供了广泛的细分。就组织起源和生物学行为而言，肿瘤被分类为不同的实体。兽药中肿瘤管理的复杂性以及动物血液学中更多免疫学标记的日益普及，促使我们提出了动物肿瘤学的REAL分类。但是，这种ML分类的相关性的证据将取决于涉及临床医生和病理学家的大型临床病理研究。

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