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首页> 外文期刊>European journal of cardio-thoracic surgery: Official journal of the European Association for Cardio-thoracic Surgery >Endothelial integrity of radial artery grafts harvested by minimally invasive surgery--immunohistochemical studies of CD31 and endothelial nitric oxide synthase expressions: a randomized controlled trial.
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Endothelial integrity of radial artery grafts harvested by minimally invasive surgery--immunohistochemical studies of CD31 and endothelial nitric oxide synthase expressions: a randomized controlled trial.

机译：微创手术收集的radial动脉移植物的内皮完整性-CD31和内皮型一氧化氮合酶表达的免疫组织化学研究：一项随机对照试验。

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摘要

OBJECTIVE: To compare the endothelial integrity of radial artery grafts harvested by minimally invasive surgery and arteries harvested conventionally for coronary artery bypass surgery (CABG) in 200 participants, who were assigned to interventions by using random allocation. METHODS: An immunohistochemical procedure with monoclonal antibodies was employed to estimate CD31 antigen and endothelial nitric oxide synthase (eNOS) expressions - markers defining endothelial integrity. RESULTS: The CD31 immunostaining revealed that the endothelial cell integrity of the minimally invasive harvested arteries was preserved in 76.1+/-7.4% of the circumference of luminal endothelium, which was similar to results obtained in conventionally harvested grafts (77.2+/-9.8%; not significant). On the other hand, eNOS immunostaining indicated that the endothelial integrity of the minimally invasive harvested grafts was preserved in 75.4+/-10.5% while in conventionally harvested grafts it was reduced to 42.4+/-14.5% of the total luminal endothelium circumference (P<0.05). CONCLUSIONS: The endothelial integrity of radial artery grafts harvested by minimally invasive surgery is better preserved than in the grafts obtained by the conventional manner. This could play an important role in improving graft patency and might represent a preliminary condition of stable functioning in coronary arterial bypasses.
机译：目的：比较由微创手术和常规冠状动脉搭桥手术（CABG）收集的radial动脉的of动脉移植物的内皮完整性，这些参与者通过随机分配被分配到干预措施中。方法：采用单克隆抗体的免疫组织化学方法评估CD31抗原和内皮一氧化氮合酶（eNOS）的表达-定义内皮完整性的标志物。结果：CD31免疫染色显示，微创收获的动脉的内皮细胞完整性在管腔内皮周长的76.1 +/- 7.4％中得以保留，这与常规收获的移植物获得的结果相似（77.2 +/- 9.8％ ; 不重要）。另一方面，eNOS免疫染色表明，微创收获的移植物的内皮完整性保持在75.4 +/- 10.5％，而在常规收获的移植物中，其完整性降低到总腔内内皮周长的42.4 +/- 14.5％（P <0.05）。结论：通过微创手术收集的radial动脉移植物的内皮完整性要比传统方式获得的移植物更好。这可能在改善移植物通畅性中起重要作用，并可能代表冠状动脉搭桥术中功能稳定的初步条件。

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