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首页> 外文期刊>European journal of cardio-thoracic surgery: Official journal of the European Association for Cardio-thoracic Surgery >Intra-thoracic fibrous tissue induction by polylactic acid and epsilon-caprolactone copolymer cubes, with or without slow release of basic fibroblast growth factor.
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Intra-thoracic fibrous tissue induction by polylactic acid and epsilon-caprolactone copolymer cubes, with or without slow release of basic fibroblast growth factor.

机译：聚乳酸和ε-己内酯共聚物的立方诱导胸腔内纤维组织，有或没有缓慢释放碱性成纤维细胞生长因子。

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Objective: We investigated whether implantation of polylactic acid and epsilon-caprolactone copolymer (PLAC) cubes with or without basic fibroblast growth factor (b-FGF) released slowly from gelatin microspheres was able to induce fibrous tissue in the dead space remaining after pneumonectomy in the thoracic cavity. Methods: Left pneumonectomy was performed in Japanese white rabbits. In the control group (n=6), the left thoracic cavity was closed without any treatment. In the FGF group (n=6), gelatin microspheres that released 100mug of b-FGF were implanted into the left thoracic cavity. In the PLAC group (n=6), PLAC cubes were implanted into the left thoracic cavity. In the PLAC/FGF group (n=6), both PLAC cubes and gelatin microspheres releasing 100mug of b-FGF were implanted into the left thoracic cavity. Results: In the control and FGF groups, herniation of the heart, mediastinal shift, and overinflation of the right lung were observed. No granular tissue formation was observed. In the PLAC and PLAC/FGF groups, a dense area of newly formed soft tissue was observed, and only a mild mediastinal shift was observed during the 3-month follow-up period. Pathological examination revealed induction of fibrous and granular tissue in the left thoracic cavity. The foreign-body reaction induced by PLAC was very mild. Conclusions: Implantation of PLAC cubes with or without gelatin microspheres releasing 100mug of b-FGF is able to induce fibrous tissue in the post-pneumonectomy dead space.
机译：目的：我们研究植入明胶微球中缓慢释放的聚乳酸和ε-己内酯共聚物（PLAC）多维数据集是否具有从明胶微球中缓慢释放的碱性成纤维细胞生长因子（b-FGF）的能力，从而能够诱导肺切除术后剩余死区的纤维组织。胸腔。方法：日本白兔行左肺切除术。对照组（n = 6），未经任何治疗就关闭了左胸腔。在FGF组（n = 6）中，将释放100mug b-FGF的明胶微球植入左胸腔。在PLAC组（n = 6）中，将PLAC立方体植入左胸腔。在PLAC / FGF组（n = 6）中，将PLAC立方体和释放100ug b-FGF的明胶微球植入左胸腔。结果：在对照组和FGF组中，观察到心脏疝，纵隔移位和右肺过度充气。没有观察到颗粒状组织形成。在PLAC和PLAC / FGF组中，观察到了新形成的软组织的致密区域，在3个月的随访期间仅观察到了轻度的纵隔移位。病理检查发现左侧胸腔中纤维状和颗粒状组织的诱导。 PLAC引起的异物反应非常轻微。结论：植入有或没有明胶微球的PLAC立方体可释放100ug的b-FGF，能够在肺切除术后死腔中诱导纤维组织。

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