...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>European Journal of Cell Biology: Journal of Deutsche Gesellschaft fur Elektronenmikroskopie: Journal of Deutsche Gesellschaft fur Zellbiologie >Fibroblast heterogeneity and its implications for engineering organotypic skin models in vitro
【24h】

Fibroblast heterogeneity and its implications for engineering organotypic skin models in vitro

机译：成纤维细胞异质性及其在体外工程器官型皮肤模型中的意义

获取原文
获取原文并翻译 | 示例
   

获取外文期刊封面封底 >>

       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Advances in cell culture methods, multidisciplinary research, clinical need to replace lost skin tissues and regulatory need to replace animal models with alternative test methods has led to development of three dimensional models of human skin. In general, these in vitro models of skin consist of keratinocytes cultured over fibroblast-populated dermal matrices. Accumulating evidences indicate that mesenchyme-derived signals are essential for epidermal morphogenesis, homeostasis and differentiation. Various studies show that fibroblasts isolated from different tissues in the body are dynamic in nature and are morphologically and functionally heterogeneous subpopulations. Further, these differences seem to be dictated by the local biological and physical microenvironment the fibroblasts reside resulting in "positional identity or memory". Furthermore, the heterogeneity among the fibroblasts play a critical role in scarless wound healing and complete restoration of native tissue architecture in fetus and oral mucosa; and excessive scar formation in diseased states like keloids and hypertrophic scars. In this review, we summarize current concepts about the heterogeneity among fibroblasts and their role in various wound healing environments. Further, we contemplate how the insights on fibroblast heterogeneity could be applied for the development of next generation organotypic skin models. (C) 2015 The Authors. Published by Elsevier GmbH.
机译：细胞培养方法，多学科研究，替换丢失的皮肤组织的临床需求以及用替代测试方法替换动物模型的监管需求的进步导致了人类皮肤三维模型的发展。通常，这些体外皮肤模型由培养在成纤维细胞填充的真皮基质上的角质形成细胞组成。越来越多的证据表明，间充质来源的信号对于表皮形态发生，体内稳态和分化至关重要。各种研究表明，从人体不同组织分离出的成纤维细胞本质上是动态的，并且在形态和功能上都是异质性亚群。此外，这些差异似乎是由成纤维细胞所驻留的局部生物学和物理微环境所决定的，从而导致“位置同一性或记忆”。此外，成纤维细胞之间的异质性在无疤伤口愈合以及胎儿和口腔粘膜中天然组织结构的完全恢复中起着至关重要的作用。在瘢痕loid和肥厚性瘢痕等疾病状态下形成过多的疤痕。在这篇综述中，我们总结了有关成纤维细胞之间异质性及其在各种伤口愈合环境中的作用的当前概念。此外，我们考虑了如何将对成纤维细胞异质性的见识应用于下一代器官型皮肤模型的开发。 （C）2015作者。由Elsevier GmbH发布。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号