Direct interaction between the ARF-specific guanine nucleotide exchangefactor msec7-1 and presynaptic Munc13-1

Neeb A.; Koch H.; Schurmann A.; Brose N.

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Direct interaction between the ARF-specific guanine nucleotide exchangefactor msec7-1 and presynaptic Munc13-1

机译：ARF特异性鸟嘌呤核苷酸交换因子msec7-1和突触前Munc13-1之间的直接相互作用

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Msec7-1, a mammalian homologue of yeast sec7p, is a specific GDP/GTP exchange factor for small G-proteins of the ARF family. Overexpression of msec7-1 in Xenopus neuromuscular junctions leads to an increase in synaptic transmitter release that is most likely caused by an increase in the pool of readily releasable vesicles. However, the molecular mechanisms by which msec7-1 is targeted to presynaptic compartments and enhances neurotransmitter release are not known. In the present study, we demonstrate that msec7-1 interacts directly with Munc13-1, a phorbol ester-dependent enhancer of neurotransmitter release that is specifically localized to presynaptic transmitter release zones. Given that Munc13-1 and msec7-1 participate in very similar presynaptic processes and because Munc13-1 is specifically targeted to presynaptic active zones, we suggest that the msec7-1/Munc13-1 interaction serves to colocalize the two proteins at the active zone, a subcellular compartment with extremely high membrane turnover.

机译：Msec7-1是酵母sec7p的哺乳动物同源物，是ARF家族小G蛋白的特定GDP / GTP交换因子。爪蟾神经肌肉接头中msec7-1的过表达导致突触递质释放的增加，这很可能是由于易于释放的囊泡池增加所致。但是，尚不知道将msec7-1靶向突触前区室并增强神经递质释放的分子机制。在本研究中，我们证明了msec7-1与Munc13-1直接相互作用，Munc13-1是一种特定于突触前递质释放区的神经递质释放的佛波酯依赖性增强剂。鉴于Munc13-1和msec7-1参与非常相似的突触前过程，并且由于Munc13-1专门针对突触前活性区，我们建议msec7-1 / Munc13-1相互作用可将两种蛋白共定位在活性区，具有极高的膜更新率的亚细胞区室。

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《European Journal of Cell Biology: Journal of Deutsche Gesellschaft fur Elektronenmikroskopie: Journal of Deutsche Gesellschaft fur Zellbiologie》 |1999年第8期|共6页
作者
Neeb A.; Koch H.; Schurmann A.; Brose N.;
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正文语种 eng
中图分类细胞生物学;
关键词
Protein protein interactions; Neurotransmitter release; Golgi apparatus; Membrane; Vesicles; Fusion; Machinery; Receptor; Targets;

机译：蛋白质相互作用;神经递质释放;高尔基体;膜;囊泡;融合;机械;受体;靶;

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1. Direct interaction between the ARF-specific guanine nucleotide exchangefactor msec7-1 and presynaptic Munc13-1 [J] . Neeb A., Koch H., Schurmann A., European Journal of Cell Biology: Journal of Deutsche Gesellschaft fur Elektronenmikroskopie: Journal of Deutsche Gesellschaft fur Zellbiologie . 1999,第8期

机译：ARF特异性鸟嘌呤核苷酸交换因子msec7-1和突触前Munc13-1之间的直接相互作用
2. Sphingosine-1-phosphate receptor S1P1 is regulated by direct interactions with P-Rex1, a Rac guanine nucleotide exchange factor. [J] . Ledezma Sanchez BA, Garcia Regalado A, Guzman Hernandez M Biochemical and Biophysical Research Communications . 2010,第4期

机译：鞘氨醇-1-磷酸受体S1P1受与Rac鸟嘌呤核苷酸交换因子P-Rex1直接相互作用的调节。
3. Heterotrimeric G protein G alpha s subunit attenuates PLEKHG2, a Rho family-specific guanine nucleotide exchange factor, by direct interaction [J] . Sugiyama Kazue, Tago Kenji, Matsushita Sayumi, Cellular Signalling . 2017,第1期

机译：异映直甲蛋白Gαs亚基衰减Plekhg2，通过直接相互作用，rho家族特异性鸟嘌呤核苷酸交换因子
4. THE INTERACTIONS OF BACTERIAL CELL DIVISION PROTEIN FtsZ WITH C8-SUBSTITUTED GUANINE NUCLEOTIDE INHIBITORS: NMR, BIOCHEMICAL AND MODEL INSIGHTS [C] . Marcelo. F., Huecas. S., Canada F.J. International Carbohydrate Symposium . 2013

机译：细菌细胞分裂蛋白FTSZ与C8取代的鸟嘌呤核苷酸抑制剂的相互作用：NMR，生物化学和模型见解
5. Interactions between the guanine nucleotide exchange factor, vav2, the platelet-derived growth factor receptor-beta and phosphoinositide 3-kinase in coronary artery vascular smooth muscle cells: Functional implications in atherosclerosis. [D] . Cushman-Vokoun, Allison Marie. 2002

机译：鸟嘌呤核苷酸交换因子，vav2，血小板衍生的生长因子受体-β和磷酸肌醇3激酶在冠状动脉血管平滑肌细胞中的相互作用：在动脉粥样硬化中的功能含义。
6. Subtle functional defects in the Arf-specific guanine nucleotide exchange factor IQSEC2 cause non-syndromic X-linked intellectual disability [O] . Cheryl Shoubridge, Randall S Walikonis, Jozef Gécz, 2010

机译：Arf特异性鸟嘌呤核苷酸交换因子IQSEC2中的细微功能缺陷会导致非综合征性X连锁智力障碍
7. Activity of the Bcr GTPase-activating Domain Is Regulated through Direct Protein/Protein Interaction with the Rho Guanine Nucleotide Dissociation Inhibitor [O] . Soo-Mi Kweon, Young Jin Cho, Parviz Minoo, 2008

机译：通过与Rho鸟嘌呤核苷酸解离抑制剂的直接蛋白质/蛋白质相互作用来调节BCR GTPase-活化结构域的活性

Direct interaction between the ARF-specific guanine nucleotide exchangefactor msec7-1 and presynaptic Munc13-1

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