Protein kinase A targeting and activation as seen by small-angle solution scattering

Trewhella J

首页> 外文期刊>European Journal of Cell Biology: Journal of Deutsche Gesellschaft fur Elektronenmikroskopie: Journal of Deutsche Gesellschaft fur Zellbiologie >Protein kinase A targeting and activation as seen by small-angle solution scattering

【24h】

Protein kinase A targeting and activation as seen by small-angle solution scattering

机译：通过小角度溶液散射观察到的蛋白激酶A靶向和激活

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

We have studied the solution structures of the multi-functional protein kinase A using small-angle X-ray and neutron scattering and have found a remarkable structural diversity in the different isoforms of this multi-subunit enzyme, in spite of its having high sequence homology and a common domain organization within its sequences. The available high-resolution crystal and NMR structural data for the protein kinase A components have aided in the interpretation of the solution scattering data and enabled us to develop models that bring insights into protein kinase A activation and targeting mechanisms, such as the opening and closing of the catalytic cleft to facilitate substrate binding or inhibition, respectively, and the role of sequence segments that join functional domains in the R subunit in providing a structurally flexible scaffold for interactions with the C subunit and A kinase-anchoring proteins (AKAPs).

机译：我们已经使用小角度X射线和中子散射研究了多功能蛋白激酶A的溶液结构，并且发现该多亚基酶的不同同工型具有显着的结构多样性，尽管它具有很高的序列同源性。以及序列中的通用域组织。蛋白激酶A组分的可用高分辨率晶体和NMR结构数据有助于解释溶液散射数据，并使我们能够开发模型，从而深入了解蛋白激酶A的激活和靶向机制，例如打开和关闭分别促进底物结合或抑制的催化裂口的形成和连接R亚基功能域的序列片段在提供结构上灵活的支架以与C亚基和A激酶锚定蛋白（AKAP）相互作用中的作用。

著录项

来源
《European Journal of Cell Biology: Journal of Deutsche Gesellschaft fur Elektronenmikroskopie: Journal of Deutsche Gesellschaft fur Zellbiologie》 |2006年第7期|共8页
作者
Trewhella J;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类细胞生物学;
关键词

相似文献

外文文献
中文文献
专利

1. Protein kinase A targeting and activation as seen by small-angle solution scattering [J] . Trewhella J European Journal of Cell Biology: Journal of Deutsche Gesellschaft fur Elektronenmikroskopie: Journal of Deutsche Gesellschaft fur Zellbiologie . 2006,第7期

机译：通过小角度溶液散射观察到的蛋白激酶A靶向和激活
2. Overcoming endocrine resistance due to reduced PTEN levels in estrogen receptor-positive breast cancer by co-targeting mammalian target of rapamycin, protein kinase B, or mitogen-activated protein kinase kinase [J] . Xiaoyong Fu, Chad J Creighton, Nrusingh C Biswal, Breast Cancer Research . 2014,第5期

机译：通过Co-靶向哺乳动物靶标，蛋白激酶B或丝裂原蛋白激酶激酶激酶的哺乳动物靶标降低了雌激素受体阳性乳腺癌中PTEN水平的内分泌抵抗力
3. Luteinizing hormone stimulates mammalian target of rapamycin signaling in bovine luteal cells via pathways independent of AKT and mitogen-activated protein kinase: modulation of glycogen synthase kinase 3 and AMP-activated protein kinase. [J] . Hou X, Arvisais EW, Davis JS Endocrinology . 2010,第6期

机译：黄体生成激素通过独立于AKT和丝裂原活化蛋白激酶的途径刺激牛黄体细胞中雷帕霉素信号的哺乳动物靶标：糖原合酶激酶3和AMP活化蛋白激酶的调节。
4. Activation of Mitogen-activated Protein Kinases and Protein Kinase B/akt Signaling By Oxidative Stress in Vascular Smooth Muscle Cells: involvement in Vascular Pathophysiology [C] . Ashok K. Srivastava, Nihar R. Pandey, Antoine Blanc International Society for Heart Research.Congress . 2004

机译：血管平滑肌细胞氧化应激激活丝裂剂活化蛋白激酶和蛋白激酶B / Akt信号传导：血管病理生理学中的参与
5. On the structure and function of calcium/calmodulin activated protein kinase II: Crystal structure of the auto-inhibited kinase domain of calcium/calmodulin-dependent kinase II and small angle X-ray scattering and electron microscopic analysis of holoenzyme assembly. [D] . Rosenberg, Oren S. 2006

机译：关于钙/钙调蛋白活化蛋白激酶II的结构和功能：钙/钙调蛋白依赖性激酶II的自抑制激酶结构域的晶体结构以及小角度X射线散射和全酶组装的电子显微镜分析。
6. Specificity of the Double-Stranded RNA-Binding Domain from the RNA-Activated Protein Kinase PKR for Double-Stranded RNA: Insights from Thermodynamics and Small-Angle X‑ray Scattering [O] . Sunita Patel, Joshua M. Blose, Joshua E. Sokoloski, -1

机译：特异性双链RNa结合从RNa活化蛋白激酶pKR双链RNa域：从热力学见解和小角度X射线散射
7. Targeting of Mitogen-Activated Protein Kinases and Phosphatidylinositol 3 Kinase Inhibits Hepatocyte Growth Factor/Scatter Factor–Induced Angiogenesis [O] . Shiladitya Sengupta, Lynda A. Sellers, Rung-Chi Li, 2003

机译：偶联偶联蛋白激酶和磷脂酰肌醇3激酶的靶向抑制肝细胞生长因子/散射因子诱导的血管生成
8. Studies of protein structure in solution and protein folding using synchrotron small-angle x-ray scattering [R] . Chen, L. 1996

机译：利用同步加速器小角X射线散射研究溶液中的蛋白质结构和蛋白质折叠

Protein kinase A targeting and activation as seen by small-angle solution scattering

摘要

著录项

相似文献

相关主题

期刊订阅