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首页> 外文期刊>Immunology and allergy clinics of North America >Allergic contact dermatitis from the vehicle components of topical pharmaceutical products
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Allergic contact dermatitis from the vehicle components of topical pharmaceutical products

机译：局部药物产品的载体成分引起的过敏性接触性皮炎

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摘要

Pharmacologically predictable adverse drug reactions and drug interactions have been commonly associated with anti-infective drugs and, particularly, antiretroviral agents. Immunologically mediated adverse drug reactions have also been commonly described in patients receiving drugs used to treat viral infections, including those used to treat human immunodeficiency virus (HIV) and hepatitis C infection. These hypersensitivity reactions associated with antiviral drugs can be classified by their immunologic mechanisms as well as their specific clinical manifestation or phenotype. Gell-Coombs types l-lll (immediate drug allergy, antibody mediated, and immune complex mechanisms) are not commonly associated with antiviral drugs. Gell-Coombs type IV (T-cell-mediated) reactions, however, have been commonly associated with drugs used to treat viral infection.
机译：药理学上可预测的不良药物反应和药物相互作用通常与抗感染药，特别是抗逆转录病毒药有关。在接受用于治疗病毒感染的药物的患者中也普遍描述了免疫学介导的药物不良反应，包括用于治疗人类免疫缺陷病毒（HIV）和丙型肝炎感染的药物。这些与抗病毒药物相关的超敏反应可以通过其免疫学机制以及特定的临床表现或表型进行分类。吉尔-库姆斯（Gell-Coombs）型（III-III）（直接药物过敏，抗体介导和免疫复合物机制）通常与抗病毒药物无关。然而，Gell-Coombs IV型（T细胞介导）反应通常与用于治疗病毒感染的药物有关。

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