Vaccine Allergy

CaubetJ.-C.; PonvertC.

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Vaccine Allergy

机译：疫苗过敏

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Adverse events after vaccine administration are commonly reported in the general population and constitute a common problem in clinical practice. The most frequent reactions after immunization are local reactions and nonimmediate skin eruptions (ie, delayed urticaria or maculopapular or nonspecific skin rashes), particularly after injection of vaccines containing toxoids and hepatitis B virus (HBV) vaccine.6"9 The literature data strongly suggest that most of these clinical manifestations do not result from a hypersensitivity reaction but, instead, from a nonspecific inflammation as reflected by the usual tolerance of booster doses.10'11 In the study by Gold and colleagues,11 only 10% of children reporting generalized allergic reactions developed a reaction on reexposure but most of these reactions were not suggestive of a hypersensitivity reaction.

机译：疫苗接种后的不良事件在一般人群中普遍报道，并且构成临床实践中的常见问题。免疫后最常见的反应是局部反应和非立即性皮疹（即荨麻疹延迟，斑丘疹或非特异性皮疹），特别是注射含类毒素和乙型肝炎病毒（HBV）疫苗的疫苗后。6“ 9文献数据强烈表明这些临床表现中的大多数并非由过敏反应引起，而是由非特异性炎症反应所致，正如通常对加强剂量的耐受性所反映的。10'11Gold和同事进行的研究11中，只有10％的儿童报告有全身性过敏反应会引起再暴露的反应，但是这些反应大多数并不表明超敏反应。

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《Immunology and allergy clinics of North America》 |2014年第3期|共17页
作者
CaubetJ.-C.; PonvertC.;
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正文语种 eng
中图分类医学免疫学;
关键词
Children; Egg; Gelatin; Hypersensitivity; Toxoids; Vaccine allergy; Vaccine components;

机译：儿童;鸡蛋;明胶;过敏;类毒素;疫苗过敏;疫苗成分;

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专利

1. Erratum: Safe administration of the seasonal trivalent influenza vaccine to children with severe egg allergy (Ann Allergy Asthma Immunol 2012;109:426-430) [J] . Annals of allergy, asthma, and immunology . 2013,第6期

机译：勘误：对严重鸡蛋过敏的儿童安全接种季节性三价流感疫苗（Ann Allergy Asthma Immunol 2012; 109：426-430）
2. Reproduction and juvenile animal toxicology studies in the rat with a new allergy vaccine adjuvanted with monophosphoryl lipid A (MPL((R))) for the treatment of grass pollen allergy. [J] . Baldrick P, Hewings S, Skinner M Reproductive toxicology . 2011,第3期

机译：用一种新的变态反应疫苗与单磷酰脂质A（MPL（R））结合治疗草花粉变态反应，在大鼠中进行生殖和少年动物毒理学研究。
3. Pollinex Quattro Ragweed: safety evaluation of a new allergy vaccine adjuvanted with monophosphoryl lipid A (MPL) for the treatment of ragweed pollen allergy. [J] . Baldrick P, Richardson D, Woroniecki SR, Journal of applied toxicology . 2007,第4期

机译：Pollinex Quattro Ragweed：一种新型抗过敏疫苗的安全性评估，该疫苗辅以单磷酰脂质A（MPL）用于治疗豚草花粉过敏。
4. Development of a Mucosal Polyvalent Allergy Vaccine for Primary Prevention of AAultisensitization [C] . U. Wiedermann, C. Wild, K. Hufnagl, Collegium Internationale Allergologicum . 2007

机译：粘膜多价过敏疫苗的开发，用于初产化初级预防
5. Synthesis and Identification of an Investigational Essential Precursor Compound for the Purpose of the Development of a Vaccine Treatment Against the Peanut Allergy. [D] . Anguella, Thomas F., Jr. 2017

机译：合成和鉴定研究必需的前体化合物，以开发针对花生过敏的疫苗。
6. Food allergy and anaphylaxis – 2045. Highly elevated IgE antibodies to vaccine components in influenza vaccine-associated anaphylaxis in Japan [O] . Mizuho Nagao, Takao Fujisawa, Toshiaki Ihara 2013

机译：食物过敏和过敏反应– 2045年。日本流感疫苗相关过敏反应中针对疫苗成分的IgE抗体高度升高
7. Comparison of the immunogenicity of BM32, a recombinant hypoallergenic B cell epitope–based grass pollen allergy vaccine with allergen extract–based vaccines [O] . Milena Weber, Katarzyna Niespodziana, Birgit Linhart, 2017

机译：BM32的免疫原性比较，一种具有过敏原提取物疫苗的重组次氧化B细胞表位的草花粉过敏疫苗

Vaccine Allergy

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