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首页> 外文期刊>Immunology and allergy clinics of North America >In vitro diagnosis of immediate IgE-mediated drug hypersensitivity: Warnings and (Unmet) Needs
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In vitro diagnosis of immediate IgE-mediated drug hypersensitivity: Warnings and (Unmet) Needs

机译：立即IgE介导的药物超敏反应的体外诊断：警告和（未满足）需求

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摘要

An excipient is an inert substance added to a drug to change dissolution or the kinetics of absorption, improve stability, influence palatability, or create a distinctive appearance. Also called additives, they are preservatives, emulsifiers, stabilizers, or thickeners. Drug hypersensitivity reactions (DHR) to them may lead to a false-positive diagnosis of DHRs to the specific active principle. Allergic contact dermatitis to drug excipients has been more thoroughly studied (see article in this issue by Goossens) than DHRs related to excipients in drugs administered systemically. We only discuss the most frequent of the latter.
机译：赋形剂是一种添加到药物中的惰性物质，可改变溶出度或吸收动力学，提高稳定性，影响适口性或形成独特的外观。也称为添加剂，它们是防腐剂，乳化剂，稳定剂或增稠剂。对他们的药物超敏反应（DHR）可能会导致DHR对特定活性成分的假阳性诊断。对药物赋形剂的过敏性接触性皮炎已经比全身给药药物中与赋形剂有关的DHR进行了更彻底的研究（请参阅本期杂志，由Goossens撰写）。我们仅讨论后者中最常见的一个。

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