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Hypersensitivity to Contrast Media and Dyes

机译:对造影剂和染料过敏

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Iodinated radiocontrast media (RCM) are concentrated solutions of tri-iodinated benzene derivatives used for diagnosis and treatment of vascular disease by enhancement of radiographic contrast. Although the risk of an adverse reaction after a single RCM administration is low, RCM are among the most common elicitors of anaphylaxis and exanthemas, owing to the administration of more than 75 million procedures per year worldwide.1 Reactions may be classified into immediate (<1 hour) or nonimmedi-ate (>1 hour after administration) hypersensitivity reactions, or toxic reactions related to the well-known toxicity of the compounds (eg, nephrotoxicity, neurotoxicity), or may also be caused by factors totally unrelated to RCM, such as chronic idiopathic urticaria (Fig. 1).
机译:碘化造影剂(RCM)是三碘化苯衍生物的浓缩溶液,可通过增强射线照相对比度来诊断和治疗血管疾病。尽管单次RCM给药后发生不良反应的风险较低,但由于在全世界每年进行超过7500万次手术,RCM是引起过敏反应和皮炎的最常见诱因之一.1反应可分为立即反应(< 1小时)或非即时(给药后> 1小时)超敏反应,或与化合物众所周知的毒性(例如,肾毒性,神经毒性)有关的毒性反应,或者也可能是由与RCM完全无关的因素引起的,例如慢性特发性荨麻疹(图1)。

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