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首页> 外文期刊>Immunology and allergy clinics of North America >Stressor-induced alterations of adaptive immunity to vaccination and viral pathogens.
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Stressor-induced alterations of adaptive immunity to vaccination and viral pathogens.

机译：应激物诱导的针对疫苗和病毒病原体的适应性免疫的改变。

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The stress response influences the immune system, and studies in laboratory animals indicate that the response to stress significantly reduces resistance to infectious challenge. Only a few studies, however, have determined the impact of the stress response on human susceptibility to infectious challenge due, in part, to the difficulties of using live, replicating pathogens in human research. As a result, many studies have assessed the immune response to vaccination as a surrogate for the immune response to an infectious challenge. Thus, much is known about how the stress response influences adaptive immunity, and memory responses, to vaccination. These studies have yielded data concerning the interactions of the nervous and immune systems and have provided important information for clinicians administering vaccines to susceptible populations. This review provides a brief overview of the immune response to commonly used vaccines and the impact that stress can have on vaccine-specific immunity.
机译：应激反应会影响免疫系统，对实验动物的研究表明，对应激的反应显着降低了对传染性攻击的抵抗力。然而，只有少数研究确定了应激反应对人类对传染病易感性的影响，部分原因是人类研究中难以使用活的，可复制的病原体。结果，许多研究评估了对疫苗接种的免疫反应，作为对传染性挑战的免疫反应的替代。因此，关于应激反应如何影响对疫苗接种的适应性免疫和记忆反应的了解很多。这些研究产生了有关神经和免疫系统相互作用的数据，并为临床医生向易感人群接种疫苗提供了重要信息。这篇综述简要概述了对常用疫苗的免疫反应以及压力对疫苗特异性免疫的影响。

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