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首页> 外文期刊>Immunology and allergy clinics of North America >Hypothalamo-pituitary-adrenocortical axis, glucocorticoids, and neurologic disease.
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Hypothalamo-pituitary-adrenocortical axis, glucocorticoids, and neurologic disease.

机译：下丘脑-垂体-肾上腺皮质轴，糖皮质激素和神经系统疾病。

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摘要

Neurologic diseases are often accompanied by significant life stress and consequent increases in stress hormone levels. Glucocorticoid stress hormones are known to have deleterious interactions with neurodegenerative processes, and are hypersecreted in neurologic disorders as well as in comorbid psychiatric conditions, such as depression. This article highlights the state of our knowledge on mechanisms controlling activation and inhibition of glucocorticoid secretion, outlines signaling mechanisms used by these hormones in neural tissue, and describes how endogenous glucocorticoids can mediate neuronal damage in various models of neurologic disease. The article highlights the importance of controlling stress and consequent stress hormone secretion in the context of neurologic disease states.
机译：神经系统疾病通常伴有严重的生活压力，并因此导致压力激素水平升高。已知糖皮质激素应激激素与神经退行性过程具有有害的相互作用，并且在神经系统疾病以及合并症的精神疾病如抑郁症中分泌过多。本文重点介绍了我们对控制糖皮质激素分泌的激活和抑制机制的认识，概述了这些激素在神经组织中使用的信号传导机制，并介绍了内源性糖皮质激素如何介导各种神经疾病模型中的神经元损伤。这篇文章强调了在神经疾病状态下控制压力和随之而来的压力激素分泌的重要性。

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