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首页> 外文期刊>Immunology: An Official Journal of the British Society for Immunology >Perturbation of the natural killer cell compartment during primary human immunodeficiency virus 1 infection primarily involving the CD56~(bright)
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Perturbation of the natural killer cell compartment during primary human immunodeficiency virus 1 infection primarily involving the CD56~(bright)

机译：主要涉及CD56〜（亮）的人类免疫缺陷病毒1感染期间自然杀伤细胞区室的扰动

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Summary:We investigated the distribution of natural killer (NK) cell subsets, their activating and inhibitory receptors, and their cytolytic potential, in primary human immunodeficiency virus (HIV)-infected (PHI) individuals at baseline and during 1 year of follow-up with or without antiretroviral therapy, and compared the results with those obtained in treatment-naive, chronically HIV-infected (CHI) individuals, and HIV-seronegative (HN) healthy individuals. The proportion of the CD56~(dim) and CD56~(bright) subsets decreased with disease progression, whereas that of the CD56~ CD16~+ subset increased. In the CD56(dim) subset, the proportion of cells with natural cytotoxicity receptors (NCRs) decreased with disease progression, and their cytolytic potential was reduced. Conversely, the CD56~(bright) subset was characterized by a high proportion of NCR-positive, killer cell immunoglobulin-like receptor (KIR)-positive NKG2A~+ cells in both CHI and PHI individuals, which was associated with an increase in their cytolytic potential. During the 1 year of follow-up, the PHI individuals with high viraemia levels and low CD4~+ T-cell counts who received highly active antiretroviral therapy (HAART) had a similar proportion of NK subsets to CHI individuals, while patients with low viraemia levels and high CD4~+ T-cell counts who remained untreated had values similar to those of the HN individuals. Our results indicate a marked perturbation of the NK cell compartment during HIV-1 infection that is multifaceted, starts early and is progressive, primarily involves the CD56~(bright) subset, and is partially corrected by effective HAART.
机译：摘要：我们在基线和随访的1年中调查了原发性人类免疫缺陷病毒（HIV）感染（PHI）个体中自然杀伤（NK）细胞亚群的分布，其激活和抑制受体及其溶细胞潜力。接受或不接受抗逆转录病毒疗法，并将结果与​​未接受过治疗的慢性HIV感染（CHI）个体和HIV血清阴性（HN）健康个体的结果进行比较。 CD56〜（dim）和CD56〜（bright）子集的比例随着疾病进展而降低，而CD56〜CD16〜+子集的比例却增加。在CD56（dim）子集中，具有自然细胞毒性受体（NCRs）的细胞比例随疾病进展而降低，并且其细胞溶解潜力降低。相反，在CHI和PHI个体中，CD56〜（亮）亚群的特征是高比例的NCR阳性，杀伤细胞免疫球蛋白样受体（KIR）阳性的NKG2A〜+细胞，这与它们的增加有关溶细胞潜力。在随访的1年中，接受高活性抗逆转录病毒疗法（HAART）的高病毒血症水平和低CD4〜+ T细胞计数的PHI患者的NK亚型比例与CHI患者相似，而低病毒血症患者未治疗的CD4 ++ T细胞水平和高水平的计数值与HN个体相似。我们的研究结果表明，HIV-1感染期间NK细胞区室的扰动是多方面的，较早开始且是进行性的，主要涉及CD56〜（亮）亚群，并通过有效的HAART进行部分纠正。

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