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首页> 外文期刊>Immunology: An Official Journal of the British Society for Immunology >Regulation of effector and memory T-cell functions by type I interferon.
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Regulation of effector and memory T-cell functions by type I interferon.

机译：I型干扰素对效应子和记忆T细胞功能的调节。

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摘要

Type I interferon (IFN-alpha/beta) is comprised of a family of highly related molecules that exert potent antiviral activity by interfering with virus replication and spread. IFN-alpha/beta secretion is tightly regulated through pathogen sensing pathways that are operative in most somatic cells. However, specialized antigen-presenting plasmacytoid dendritic cells are uniquely equipped with the capacity to secrete extremely high levels of IFN-alpha/beta, suggesting a key role for this cytokine in priming adaptive T-cell responses. Recent studies in both mice and humans have demonstrated a role for IFN-alpha/beta in directly influencing the fate of both CD4(+) and CD8(+) T cells during the initial phases of antigen recognition. As such, IFN-alpha/beta, among other innate cytokines, is considered an important 'third signal' that shapes the effector and memory T-cell pool. Moreover, IFN-alpha/beta also serves as a counter-regulator of T helper type 2 and type 17 responses, which may be important in the treatment of atopy and autoimmunity, and in the development of novel vaccine adjuvants.
机译：I型干扰素（IFN-α/β）由一系列高度相关的分子组成，这些分子通过干扰病毒的复制和传播发挥有效的抗病毒活性。 IFN-α/β的分泌是通过在大多数体细胞中起作用的病原体传感途径严格控制的。但是，专门提呈抗原的浆细胞样树突状细胞独特地具备分泌极高水平的IFN-α/β的能力，这表明该细胞因子在引发适应性T细胞反应中起关键作用。在小鼠和人类中的最新研究表明，在抗原识别的初始阶段，IFN-α/β可直接影响CD4（+）和CD8（+）T细胞的命运。因此，在其他先天细胞因子中，IFN-α/β被认为是一个重要的“第三信号”，可影响效应细胞和记忆T细胞池。此外，IFN-α/β还可以作为2型和17型T辅助反应的反调节剂，这在特应性疾病和自身免疫性治疗以及新型疫苗佐剂的开发中可能很重要。

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