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首页> 外文期刊>Immunology: An Official Journal of the British Society for Immunology >Viral (hepatitis C virus, hepatitis B virus, HIV) persistence and immune homeostasis
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Viral (hepatitis C virus, hepatitis B virus, HIV) persistence and immune homeostasis

机译：病毒（丙型肝炎病毒，乙型肝炎病毒，艾滋病毒）的持久性和免疫稳态

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摘要

Immune homeostasis is a host characteristic that maintains biological balance within a host. Humans have evolved many host defence mechanisms that ensure the survival of individuals upon encountering a pathogenic infection, with recovery or persistence from a viral infection being determined by both viral factors and host immunity. Chronic viral infections, such as hepatitis B virus, hepatitis C virus and HIV, often result in chronic fluctuating viraemia in the face of host cellular and humoral immune responses, which are dysregulated by multi-faceted mechanisms that are incompletely understood. This review attempts to illuminate the mechanisms involved in this process, focusing on immune homeostasis in the setting of persistent viral infection from the aspects of host defence mechanism, including interferon-stimulated genes, apolipoprotein B mRNA editing enzyme catalytic polypeptide 3 (APOBEC3), autophagy and interactions of various immune cells, cytokines and regulatory molecules.
机译：免疫稳态是维持宿主体内生物平衡的宿主特征。人类已经进化出许多宿主防御机制，这些机制可确保个体在遇到病原体感染后得以生存，病毒感染的恢复或持久性取决于病毒因素和宿主免疫力。面对乙型肝炎病毒，丙型肝炎病毒和艾滋病毒等慢性病毒感染，面对宿主的细胞和体液免疫反应，通常会导致慢性波动的病毒血症，而这是由于多方面的机制所致。这篇综述试图阐明该过程涉及的机制，从宿主防御机制的方面着眼于持续病毒感染情况下的免疫稳态，包括干扰素刺激基因，载脂蛋白B mRNA编辑酶催化多肽3（APOBEC3），自噬以及各种免疫细胞，细胞因子和调节分子的相互作用。

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