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首页> 外文期刊>Immunology: An Official Journal of the British Society for Immunology >CD4+ T-cell Inhibitory Ligands: A Tool for characterizing dysfunctional CD4+ T cells during Chronic Infection
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CD4+ T-cell Inhibitory Ligands: A Tool for characterizing dysfunctional CD4+ T cells during Chronic Infection

机译：CD4 + T细胞抑制配体：慢性感染过程中表征功能异常的CD4 + T细胞的工具

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摘要

Activation of CD4+ T cells helps to establish and maintain immune responses. During infection with lymphocytic choriomeningitis virus (LCMV) clone 13, the CD4+ T-cell responses are lost. In this study, we were interested in the nature of the CD4+ T-cell responses following infection with LCMV clone 13. To pursue this question, we infected C57BL/6 mice with LCMV clone 13. We used a GP66-80 MHC Class II tetramer to determine whether the CD4+ T cells were present following infection with LCMV clone 13. We determined that the cells were present and antigen specific, but not functional. We attributed their dysfunction to the presence of CD4+ T-cell inhibitory ligands. We further stained for the presence of CD4+ T-cell inhibitory ligands. We found that the during chronic infection the number of CD4+ T cells expressing programmed death-1 and CD160 were greater over the time-course study than the other CD4+ T-cell inhibitory ligands. These data show that using CD4+ T-cell inhibitory ligands as a reagent for characterization can help in understanding the complex immune responses associated with persistent infections.
机译：CD4 + T细胞的激活有助于建立和维持免疫应答。在感染淋巴细胞性脉络膜脑膜炎病毒（LCMV）克隆13期间，CD4 + T细胞反应消失。在这项研究中，我们对LCMV克隆13感染后CD4 + T细胞应答的性质感兴趣。为了解决这个问题，我们用LCMV克隆13感染了C57BL / 6小鼠。我们使用了GP66-80 MHC II类四聚体以确定在感染LCMV克隆13后是否存在CD4 + T细胞。我们确定存在细胞且具有抗原特异性，但没有功能。我们将其功能障碍归因于CD4 + T细胞抑制性配体的存在。我们进一步对CD4 + T细胞抑制性配体的存在进行了染色。我们发现，在慢性感染过程中，经过时程研究，表达编程性死亡1和CD160的CD4 + T细胞的数量大于其他CD4 + T细胞抑制性配体。这些数据表明，使用CD4 + T细胞抑制性配体作为表征试剂可以帮助理解与持续性感染相关的复杂免疫反应。

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