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首页> 外文期刊>Immunology: An Official Journal of the British Society for Immunology >Epicutaneous immunization converts subsequent and established antigen-specific T helper type 1 (Th1) to Th2-type responses.
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Epicutaneous immunization converts subsequent and established antigen-specific T helper type 1 (Th1) to Th2-type responses.

机译：表皮免疫将随后建立的抗原特异性T辅助1型（Th1）转换为Th2型应答。

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Epicutaneous immunization is a potential novel technique for topical vaccine delivery. It targets the immunologically rich milieu of the skin while having the advantage of being a non-invasive immunization procedure. By disrupting the stratum corneum of the epidermis a natural adjuvant effect can be achieved through activation of resident Langerhans cells. This negates the normal need for co-application of noxious adjuvants. Epicutaneous immunization on barrier-disrupted skin induces potent antigen-specific systemic immunity with a strong T helper type 2 (Th2) bias. We show here that epicutaneous immunization enhances the vigour of a subsequent T-cell response to the same antigen. The induced systemic Th2 response prevents the development of Th1 responses induced through injection of antigen in complete Freund's adjuvant (CFA). Prior epicutaneous immunization results in reduced production of antigen-specific interferon-gamma and immunoglobulin G2a (IgG2a) and enhanced interleukin-4, IgG1 and IgE responses to immunization with CFA. Moreover, epicutaneous immunization converts an established Th1 response to a Th2 response, as demonstrated by the specific reduction of interferon-gamma and IgG2a and the enhancement of interleukin-4 and IgE. This Th2 dominance of epicutaneous immunization may have direct therapeutic application as an immune-modulating procedure in Th1-dominant diseases such as autoimmune rheumatoid arthritis, type 1 diabetes, Hashimoto's thyroiditis and multiple sclerosis.
机译：表皮免疫是用于局部疫苗递送的潜在新技术。它以皮肤的免疫学丰富的环境为目标，同时具有非侵入性免疫程序的优势。通过破坏表皮的角质层，可以通过激活常驻朗格汉斯细胞来达到天然的佐剂作用。这消除了共同使用有毒佐剂的正常需求。在屏障被破坏的皮肤上进行表皮免疫可诱导强效的抗原特异性全身免疫，并具有强烈​​的2型T辅助（Th2）偏倚。我们在这里显示，表皮免疫增强了对相同抗原的后续T细胞反应的活力。诱导的全身性Th2反应阻止了通过在完全弗氏佐剂（CFA）中注射抗原诱导的Th1反应的发展。先前的表皮免疫可降低抗原特异性干扰素-γ和免疫球蛋白G2a（IgG2a）的产生，并增强白介素4，IgG1和IgE对CFA免疫的反应。此外，如干扰素-γ和IgG2a的特异性降低以及白介素4和IgE的增强所证明的，表皮免疫将已建立的Th1反应转化为Th2反应。表皮免疫的这种Th2优势可以作为免疫调节方法直接治疗Th1占主导地位的疾病，例如自身免疫性类风湿性关节炎，1型糖尿病，桥本甲状腺炎和多发性硬化症。

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