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首页> 外文期刊>Immunology: An Official Journal of the British Society for Immunology >Oestradiol potentiates the suppressive function of human CD4 CD25 regulatory T cells by promoting their proliferation.
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Oestradiol potentiates the suppressive function of human CD4 CD25 regulatory T cells by promoting their proliferation.

机译：雌二醇通过促进人CD4 CD25调节性T细胞的增殖来增强其抑制功能。

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摘要

CD4+ CD25+ regulatory T (Treg) cells play an important role in the control of the immune system by suppressing the proliferation of effector cells, thereby preventing autoreactive, unnecessary or inconvenient responses. Recently, it has been shown that the number of Treg cells increases during pregnancy, a period with high serum levels of female sex hormones. Oestrogen replacement therapy has been reported to alleviate the symptoms of autoimmune diseases, yet the cellular and molecular mechanisms involved are not fully understood. Here, we show that physiological doses of oestradiol (E2) found during pregnancy, combined with activation through CD3/CD28 engagement, promoted the proliferation of Treg cells without altering their suppressive phenotype. Enhanced suppression was detected when Treg cells were pretreated with the hormone as well as when both cell subpopulations (Treg and T effector) were exposed to E2 throughout the experiment. Together, these data suggest that when combined with an activating stimulus, E2 can modulate the function of human Treg cells by regulating their numbers, and highlight a potential use of E2, or its analogs, to manipulate Treg function.
机译：CD4 + CD25 +调节性T细胞（Treg）通过抑制效应细胞的增殖，从而在自身免疫系统的控制中发挥重要作用，从而防止自身反应，不必要或不便的反应。最近，已经显示出在怀孕期间Treg细胞的数量增加，这是女性性激素的血清水平高的时期。据报道雌激素替代疗法可减轻自身免疫性疾病的症状，但尚未完全了解所涉及的细胞和分子机制。在这里，我们表明，怀孕期间发现的生理剂量的雌二醇（E2）与通过CD3 / CD28参与的激活相结合，可促进Treg细胞的增殖，而不会改变其抑制表型。当用激素对Treg细胞进行预处理以及整个实验过程中两个细胞亚群（Treg和T效应子）都暴露于E2时，检测到抑制作用增强。总之，这些数据表明，当与激活刺激物结合时，E2可以通过调节人类Treg细胞的数量来调节其功能，并突显了E2或其类似物在操纵Treg功能方面的潜在用途。

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