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首页> 外文期刊>Immunology: An Official Journal of the British Society for Immunology >The T-cell receptor repertoire of regulatory T cells.
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The T-cell receptor repertoire of regulatory T cells.

机译：调节性T细胞的T细胞受体库。

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摘要

The CD4(+) CD25(+) regulatory population of T cells (Treg cells), which expresses the forkhead family transcription factor (Foxp3), is the key component of the peripheral tolerance mechanism that protects us from a variety of autoimmune diseases. Experimental evidence shows that Treg cells recognize a wide range of antigenic specificities with increased reactivity to self antigens, although the affinity of these interactions remains to be further defined. The Treg repertoire is highly diverse with a distinct set of T-cell receptors (TCRs), and yet is overlapping to some extent with the repertoire of conventional T cells (Tconv cells). The majority of Treg cells are generated in the thymus. However, the role of the TCR specificity in directing thymic precursors to become Treg or Tconv cells remains unclear. On the one hand, the higher self reactivity of Treg cells and utilization of different TCRs in Treg and Tconv repertoires suggest that in TCR interactions an initial decision is made about the 'suitability' of a developing thymocyte to become a Treg cell. On the other hand, as Treg cells can recognize a wide range of foreign antigens, have a diverse TCR repertoire, and show some degree of overlap with Tconv cells, the signals through the TCR may be complementary to the TCR-independent process that generates precursors of Treg cells. In this review, we discuss how different features of the Treg repertoire influence our understanding of Treg specificities and the role of self reactivity in the generation of this population.
机译：表达叉头家族转录因子（Foxp3）的T细胞（Treg细胞）的CD4（+）CD25（+）调节种群是外周耐受机制的关键组成部分，可以保护我们免受各种自身免疫性疾病的侵害。实验证据表明，Treg细胞可识别多种抗原特异性，并且对自身抗原的反应性增强，尽管这些相互作用的亲和力仍有待进一步确定。 Treg的库非常丰富，具有一组独特的T细胞受体（TCR），但在一定程度上与常规T细胞（Tconv细胞）的库重叠。 Treg细胞的大部分在胸腺中产生。但是，TCR特异性在指导胸腺前体变为Treg或Tconv细胞方面的作用尚不清楚。一方面，Treg细胞的更高的自我反应性以及Treg和Tconv曲目中不同TCR的利用表明，在TCR相互作用中，初步决定了发育中的胸腺细胞是否适合成为Treg细胞。另一方面，由于Treg细胞可以识别广泛的外源抗原，具有多样化的TCR组成，并显示与Tconv细胞的某种程度的重叠，因此通过TCR传递的信号可能与产生前体的非TCR独立过程互补Treg细胞。在这篇综述中，我们讨论了Treg组成成分的不同特征如何影响我们对Treg特异性的理解以及自我反应在该群体的产生中的作用。

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