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首页> 外文期刊>Immunology: An Official Journal of the British Society for Immunology >Low-dose antigen-experienced CD4+ T cells display reduced clonal expansion but facilitate an effective memory pool in response to secondary exposure.
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Low-dose antigen-experienced CD4+ T cells display reduced clonal expansion but facilitate an effective memory pool in response to secondary exposure.

机译：低剂量抗原经历的CD4 + T细胞显示出较低的克隆扩增能力，但有助于响应二次暴露而形成有效的记忆库。

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摘要

The strength and duration of an antigenic signal at the time of initial stimulation were assumed to affect the development and response of effectors and memory cells to secondary stimulation with the same antigen. To test this assumption, we used T-cell receptor (TCR)-transgenic CD4+ T cells that were stimulated in vitro with various antigen doses. The primary effector CD4+ T cells generated in response to low-dose antigen in vitro exhibited reduced clonal expansion upon secondary antigenic exposure after adoptive transfer to hosts. However, the magnitude of their contraction was much smaller than both those generated by high-dose antigen stimulation and by naive CD4+ T cells, resulting in higher numbers of antigen-specific CD4+ T cells remaining until the memory stage. Moreover, secondary effectors and memory cells developed by secondary antigen exposure were not functionally impaired. In hosts given the low-dose antigen-experienced CD4+ T cells, we also observed accelerated recall responses upon injection of antigen-bearing antigen-presenting cells. These results suggest that primary TCR stimulation is important for developing optimal effectors during initial antigen exposure to confer long-lasting memory CD4+ T cells in response to secondary exposure.
机译：假设在初始刺激时抗原信号的强度和持续时间会影响效应子和记忆细胞对相同抗原的二次刺激的发育和反应。为了检验这一假设，我们使用了在体外用各种抗原剂量刺激的T细胞受体（TCR）转基因CD4 + T细胞。在体外对低剂量抗原的应答中产生的初级效应CD4 + T细胞在继代转移至宿主后的次级抗原暴露中表现出降低的克隆扩增。然而，它们的收缩幅度远小于高剂量抗原刺激和幼稚的CD4 + T细胞产生的收缩幅度，导致直到记忆期还剩下更多数量的抗原特异性CD4 + T细胞。而且，通过二次抗原暴露产生的二次效应物和记忆细胞没有功能受损。在给予了低剂量抗原经历的CD4 + T细胞的宿主中，我们还观察到注射了带有抗原的抗原呈递细胞后加速的召回反应。这些结果表明，初次TCR刺激对于在初次抗原暴露过程中开发最佳效应子以响应二次暴露而赋予持久的记忆CD4 + T细胞很重要。

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