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首页> 外文期刊>Immunology, endocrine & metabolic agents in medicinal chemistry. >Q Fever and Coxiella burnetii: Immune Response and Pathogenesis
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Q Fever and Coxiella burnetii: Immune Response and Pathogenesis

机译：Q发热和柯氏杆菌：免疫反应和发病机理。

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Coxiella burnetii is the intracellular bacterium responsible for Q fever and is classified as a category B potential biological weapon. Primary infection by C. burnetii is often asymptomatic or mild and is accompanied by spontaneous recovery. In patients with valve lesions or immunosuppressed patients, including pregnant women, the infection may become chronic. C. burnetii survives and replicates within myeloid cells by subverting receptor-mediated phagocytosis and preventing phagosome maturation. Here, we summarize the existing knowledge regarding the host response to C. burnetii; we also discuss the mechanisms used by C. burnetii to survive within macrophages as well as the defective immune response that characterizes chronic Q fever.
机译：柯氏杆菌是引起Q发热的细胞内细菌，被归类为B类潜在生物武器。伯氏梭菌的原发感染通常是无症状或轻度的，并伴有自然恢复。在有瓣膜病变或免疫抑制的患者（包括孕妇）中，感染可能会变成慢性。通过破坏受体介导的吞噬作用并防止吞噬体成熟，伯氏梭菌得以在髓样细胞中存活并复制。在这里，我们总结了有关宿主对伯氏梭菌的反应的现有知识。我们还讨论了伯氏梭状芽孢杆菌在巨噬细胞中存活的机制，以及表征慢性Q热的缺陷免疫反应。

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