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首页> 外文期刊>Immunology: An Official Journal of the British Society for Immunology >Regulation of CD4+ T-cell polarization by suppressor of cytokine signalling proteins.
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Regulation of CD4+ T-cell polarization by suppressor of cytokine signalling proteins.

机译：CD4 + T细胞极化的细胞因子信号转导蛋白抑制剂的调节。

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Suppressors of cytokine signalling (SOCS) proteins are induced in responses to many stimuli and by binding to cytokine receptors and associated janus kinase (JAK) proteins, directly regulate the activation of the signal transducers and activators of transcription (STATs). STAT proteins regulate the expression of many genes required for the differentiation of various CD4(+) T helper cell lineages, and there is now accumulating evidence that SOCS also play essential roles in the regulation and maintenance of CD4(+) T-cell polarization. As it is now clear that CD4(+) T cells are more plastic than initially thought, it is of particular importance to understand the molecular mechanisms regulating CD4(+) T-cell differentiation. Here we review the current understanding of how STATs and SOCS act in concert to influence the polarization of CD4(+) T cells and highlight the relevance of this in disease.
机译：细胞因子信号转导（SOCS）蛋白的抑制剂是在对许多刺激的响应中诱导的，并且通过与细胞因子受体和相关的janus激酶（JAK）蛋白结合而直接调节信号转导子和转录激活子（STATs）的激活。 STAT蛋白调节分化各种CD4（+）T辅助细胞谱系所需的许多基因的表达，现在有越来越多的证据表明SOCS在CD4（+）T细胞极化的调节和维持中也起着重要作用。现在很明显，CD4（+）T细胞比最初的想象更具塑性，了解调节CD4（+）T细胞分化的分子机制尤为重要。在这里，我们回顾当前对STATs和SOCS如何协同作用以影响CD4（+）T细胞极化的理解，并强调其在疾病中的相关性。

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