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NKp30 isoforms in patients with chronic hepatitis C virus infection

机译：慢性丙型肝炎病毒感染患者的NKp30亚型

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摘要

Natural killer (NK) cells play an important role in virus infection, their action being regulated by several activating and inhibitory receptors. The NKp30 activating receptor and its isoforms have recently emerged as important determinants of efficient NK cell responses. We determined the relative proportions of NKp30 isoforms in patients with chronic hepatitis C virus (HCV) infection and healthy donors (HD). NK cell function (degranulation and cytokine production) and correlations with clinical parameters were assessed following unsupervised hierarchical clustering of patients according to isoform expression. NKp30 receptor expression on NK cells and all isoforms were reduced in HCV-infected patients. Patients were clustered into two groups: the HCV-1 group had similar isoform expression to the HD group, whereas the HCV-2 group had lower expression. The latter showed a better functional activity, and a higher proportion of the activating a isoform and of the NKp30 isoform a/c ratio compared with the HCV-1 cluster. There was a positive correlation between the activating a isoform and liver stiffness and an inverse relationship between the immunosuppressive c isoform and the fibrosis 4 score, suggesting a potentially important role of NKp30 isoforms in influencing liver damage and ensuing fibrosis.
机译：天然杀伤（NK）细胞在病毒感染中起重要作用，其作用受几种活化和抑制受体的调节。 NKp30激活受体及其同工型最近已成为有效NK细胞反应的重要决定因素。我们确定了慢性丙型肝炎病毒（HCV）感染患者和健康捐赠者（HD）患者中NKp30亚型的相对比例。根据同工型表达，在无监督的患者分层聚类后，评估了NK细胞功能（脱颗粒和细胞因子产生）以及与临床参数的相关性。在HCV感染的患者中，NK细胞和所有同工型上的NKp30受体表达降低。患者分为两组：HCV-1组与HD组具有相似的同工型表达，而HCV-2组具有较低的表达。与HCV-1簇相比，后者显示出更好的功能活性，并且活化同工型和NKp30同工型a / c比率的比例更高。激活亚型和肝硬度之间存在正相关，而免疫抑制c异构体与纤维化4评分之间呈负相关，这表明NKp30亚型在影响肝损伤和随后的纤维化中具有潜在的重要作用。

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