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首页> 外文期刊>Immunology: An Official Journal of the British Society for Immunology >The life (and death) of CD4(+) CD28(null) T cells in inflammatory diseases
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The life (and death) of CD4(+) CD28(null) T cells in inflammatory diseases

机译：CD4（+）CD28（null）T细胞在炎症性疾病中的生命（和死亡）

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摘要

Inflammation contributes to the development and perpetuation of several disorders and T lymphocytes orchestrate the inflammatory immune response. Although the role of T cells in inflammation is widely recognized, specific therapies that tackle inflammatory networks in disease are yet to be developed. CD4(+)CD28(null) T cells are a unique subset of helper T lymphocytes that recently shot back into the limelight as potential catalysts of inflammation in several inflammatory disorders such as autoimmunity, atherosclerosis and chronic viral infections. In contrast to conventional helper T cells, CD4(+) CD28(null) T cells have an inbuilt ability to release inflammatory cytokines and cytotoxic molecules that can damage tissues and amplify inflammatory pathways. It comes as no surprise that patients who have high numbers of these cells have more severe disease and poor prognosis. In this review, I provide an overview on the latest advances in the biology of CD4(+) CD28(null) T cells. Understanding the complex functions and dynamics of CD4(+) CD28(null) T cells may open new avenues for therapeutic intervention to prevent progression of inflammatory diseases.
机译：炎症会导致多种疾病的发展和长存，而T淋巴细胞会协调炎症免疫反应。尽管T细胞在炎症中的作用已得到广泛认可，但针对疾病中炎症网络的特定疗法尚待开发。 CD4（+）CD28（null）T细胞是辅助T淋巴细胞的独特子集，最近又重新成为众人关注的辅助T淋巴细胞，成为多种炎症性疾病（如自身免疫性，动脉粥样硬化和慢性病毒感染）中潜在的炎症催化剂。与传统的辅助性T细胞相反，CD4（+）CD28（null）T细胞具有释放发炎性细胞因子和细胞毒性分子的内在能力，后者可破坏组织并放大发炎途径。拥有大量此类细胞的患者疾病更严重，预后不良也就不足为奇了。在本文中，我概述了CD4（+）CD28（null）T细胞生物学的最新进展。了解CD4（+）CD28（null）T细胞的复杂功能和动力学可能为治疗性干预开辟新途径，以预防炎症性疾病的进展。

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