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首页> 外文期刊>Immunology: An Official Journal of the British Society for Immunology >Interleukin-21 suppresses the differentiation and functions of T helper 2 cells
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Interleukin-21 suppresses the differentiation and functions of T helper 2 cells

机译：白细胞介素21抑制T辅助细胞2的分化和功能

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摘要

T helper type 2 (Th2) cells, which produce interleukin-4 (IL-4), IL-5 and IL-13, control immunity to all forms of allergic inflammatory responses. Interleukin-21 (IL-21) reduces allergic symptoms in murine models and inhibits IL-4-induced IgE secretion by B cells. However, whether or not IL-21 directly affects Th2 cells, which leads to reduced allergic symptoms, is unclear. In this study, we investigated the effects of IL-21 on the differentiation and effector functions of Th2 cells. We found that IL-21 reduced the number of differentiated Th2 cells and these Th2 cells showed a diminished Th2 cytokine production. Interleukin-21 suppressed Th2 cytokine production of already polarized Th2 cells by down-regulation of transcription factor GATA-3. It also induced apoptosis of Th2 cells with decreased anti-apoptotic factor Bcl-2. Intranasal administration of IL-21 at the beginning of ovalbumin (OVA) sensitization or before OVA challenge decreased Th2 cytokines in the bronchoalveolar lavage fluid of OVA/alum-immunized allergic mice. In addition, the inhibitory effects of IL-21 on Th2 effector functions can also be found in allergic patients. Our results demonstrate that IL-21 suppresses the development of Th2 cells and functions of polarized Th2 cells. Hence, the administration of IL-21 may be considered for use as a preventive and therapeutic approach when dealing with Th2-mediated allergic diseases.
机译：产生白介素4（IL-4），IL-5和IL-13的2型T辅助细胞（Th2）控制对所有形式的过敏性炎症反应的免疫力。白介素21（IL-21）减轻了鼠模型的过敏症状，并抑制了B细胞IL-4诱导的IgE分泌。但是，尚不清楚IL-21是否直接影响Th2细胞，从而导致过敏症状减轻。在这项研究中，我们研究了IL-21对Th2细胞分化和效应功能的影响。我们发现IL-21减少了分化的Th2细胞的数量，这些Th2细胞显示Th2细胞因子产生减少。白介素21通过下调转录因子GATA-3抑制已经极化的Th2细胞的Th2细胞因子产生。它还诱导抗凋亡因子Bcl-2减少的Th2细胞凋亡。在卵清蛋白（OVA）致敏开始时或在卵清蛋白刺激之前，鼻腔给予IL-21可以减少卵白蛋白（OVA）/经免疫铝的变应性小鼠的支气管肺泡灌洗液中的Th2细胞因子。另外，在过敏患者中也可以发现IL-21对Th2效应子功能的抑制作用。我们的结果表明，IL-21抑制Th2细胞的发育和极化Th2细胞的功能。因此，当处理Th2介导的过敏性疾病时，IL-21的施用可以被认为是预防和治疗方法。

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