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首页> 外文期刊>Immunology: An Official Journal of the British Society for Immunology >Increased proportion of CD56bright natural killer cells in active and inactive systemic lupus erythematosus.
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Increased proportion of CD56bright natural killer cells in active and inactive systemic lupus erythematosus.

机译：在活跃和不活跃的系统性红斑狼疮中，CD56bright自然杀伤细胞的比例增加。

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Natural killer (NK) cells belong to the innate immune system but can also affect adaptive immune reactions. This immune regulatory function is often ascribed to the CD56(bright) subpopulation of NK cells that is prevalent in secondary lymphoid tissues and has potent cytokine-producing ability. The NK cells have been described as affecting autoimmune disease and stimulating B-cell production of antibodies, but their role in systemic lupus erythematosus (SLE) pathology has not been extensively studied. We have studied NK cells in SLE, a B-cell-driven systemic autoimmune disease, and phenotypically characterized peripheral blood NK cells in comparison to NK cells from patients with immunoglobulin A nephritis, rheumatoid arthritis and healthy individuals. We have found an increased proportion of CD56(bright) NK cells in SLE, regardless of disease activity. We detected a somewhat increased expression of the activating receptor NKp46/CD335 on NK cells from SLE patients, although neither the percentage of NK cells of all lymphocytes nor the expression of other NK receptors analysed (LIR-1/CD85j, CD94, NKG2C/CD159c, NKG2D/CD314, NKp30/CD337, NKp44/CD336, CD69) differed between patient groups. We show that type I interferon, a proinflammatory cytokine known to be abundant in SLE, can cause increases of CD56(bright) NK cells in vitro. We confirmed that serum levels of interferon-alpha were increased in active, but not in inactive, disease in the SLE patient group. In conclusion, we found an increased proportion of CD56(bright) NK cells in the blood of SLE patients, although it remains to be examined whether and how this relates to the disease process.
机译：自然杀伤（NK）细胞属于先天免疫系统，但也会影响适应性免疫反应。这种免疫调节功能通常归因于NK细胞的CD56（亮）亚群，该亚群普遍存在于次级淋巴组织中，并具有有效的细胞因子产生能力。 NK细胞已被描述为影响自身免疫性疾病并刺激B细胞产生抗体，但尚未广泛研究其在系统性红斑狼疮（SLE）病理中的作用。我们已经研究了SLE中的NK细胞，这是一种B细胞驱动的系统性自身免疫性疾病，并且与免疫球蛋白A肾炎，类风湿性关节炎和健康个体的NK细胞相比，具有表型特征的外周血NK细胞。我们发现，无论疾病活动如何，SLE中CD56（亮）NK细胞的比例均增加。尽管未分析所有淋巴细胞的NK细胞百分比或所分析的其他NK受体的表达（LIR-1 / CD85j，CD94，NKG2C / CD159c），但我们检测到SLE患者NK细胞上激活受体NKp46 / CD335的表达有所增加。 ，NKG2D / CD314，NKp30 / CD337，NKp44 / CD336，CD69）在患者组之间有所不同。我们显示，I型干扰素是一种已知在SLE中丰富的促炎细胞因子，在体外可引起CD56（亮）NK细胞增加。我们确认，SLE患者组中活动性疾病的血清干扰素-α水平升高，但非活动性疾病的血清中α-干扰素水平并未升高。总之，我们发现SLE患者血液中CD56（亮）NK细胞的比例增加，尽管尚需检查其是否与疾病过程相关以及如何与疾病过程相关。

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